复方地利乳膏的制备及含量测定  

Preparation and Content Determination of Compound Dexamethasone Sodium Phosphate/Lidocaine Hydrochloride Cream

作　　者：陈立[1,2] 陈宇星[1,2] 林佳[3] 

机构地区：[1]福建医科大学省立临床医学院 [2]福建省立医院,福州市350001 [3]福建中医学院药学系,福州市350108

出　　处：《中国药房》2010年第41期3898-3900,共3页China Pharmacy

摘　　要：目的:制备复方地利乳膏并建立其含量测定方法。方法:以地塞米松磷酸钠、盐酸利多卡因为主药,采用乳化剂后加法制备乳膏;利用高效液相色谱法同时测定制剂中2主药的含量。结果:所制制剂为水包油型乳膏;地塞米松磷酸钠、盐酸利多卡因检测浓度的线性范围分别为32.38～48.58、304.16～456.24μg·mL-(1r=0.9999);平均回收率分别为98.0%、102.0%(n=9);RSD分别为0.08%、0.21%。结论:该制剂处方工艺简单、可行,含量测定方法准确、简便。OBJECTIVE：To prepare Compound dexamethasone sodium phosphate/lidocaine hydrochloride cream and to establish content determination method of it.METHODS：Preparation was prepared using dexamethasone sodium phosphate and lidocaine hydrochloride as main components then adding emulsifier.The contents of dexamethasone sodium phosphate and lidocaine hydrochloride were determined by HPLC.RESULTS：Prepared cream was O/W cream.The linear ranges were 32.38～48.58 μg·mL-1（r=0.999 9） for dexamethasone sodium phosphate and 304.16～456.24 μg·mL-1 for lidocaine hydrochloride.The average recovery rates were 98.0%（n=9）,RSD=0.08% for dexamethasone sodium phosphate,and 102.0%（n=9）,RSD=0.21% for lidocaine hydrochloride.CONCLUSION：The formulation process is simple and feasible,and the content determination method is simple and accurate.

关 键 词：复方地利乳膏 地塞米松磷酸钠 盐酸利多卡因 制备 含量测定 高效液相色谱法 

分 类 号：R927.2[医药卫生—药学] R986