小鼠埋植聚(羟烷基)-DL-天冬酰胺的初步观察  

PRELIMINARY OBSERVATION OF POLY(HYDROXYALKYL) DL ASPARAMIDE IMPLANTATION IN MICE

作　　者：翁立红[1] 汤谷平[1] 周俊 王斌 

机构地区：[1]浙江医科大学组织胚胎教研室

出　　处：《中国医药工业杂志》1999年第5期213-215,共3页Chinese Journal of Pharmaceuticals

基　　金：国家自然科学基金

摘　　要：为了解聚－（羟乙基）－ＤＬ－天冬酰胺（１）和聚－（羟丙基）－ＤＬ－天冬酰胺（２）在体内的变化过程及对肝肾的影响，将１和２压制成棒，埋于小鼠皮下，分别于ｄ５、１０、１５、２０取埋植部位、肝、肾组织作组织切片，取血检测丙氨酸转氨酶、肌酐。结果显示：１和２均有溶胀分解现象，经历了从固态到胶状再到细小颗粒的变化过程。两者被吸收后，可引起肝脏小血管周围的轻度炎症反应，肾小管内出现小量管型。The degradation process of poly α,β [ N (hydroxyethyl)] DL asparamide (1) and poly α,β (hydroxypropyl) DL asparamide (2) in liver and kidney after subcutaneous implantation in mice was investigated. The histopathological changes of implantation site, liver and kidney were observed. The ALT and Cr values were estimated. The results showed that the 1 and 2 changed in the similar way in mice, from solid state to colloidal state, and then forming many small particles. There was a slight inflammation around the small blood vessels of liver. The casts were found in some renal tubules. The functions of liver and kidney were normal.

关 键 词：天冬酰胺 羟烷基 皮下埋植 分解 药物载体 

分 类 号：TQ460.4[化学工程—制药化工] R944.9[医药卫生—药剂学]