内源性地高辛样物质的临床意义及其检测方法  

Clinical Significance and Detection Methods of Endogenous Digoxin-like Substances

作　　者：肖晨[1] 傅善基[1] 

机构地区：[1]山东大学齐鲁医院检验科,济南250012

出　　处：《生物医学工程研究》2010年第3期206-210,共5页Journal Of Biomedical Engineering Research

摘　　要：内源性地高辛样物质(EDLS)是体内产生和分泌的一种具有洋地黄样生物活性的物质,具有强心、利尿、缩血管的作用,参与诸多疾病的发生发展,近来研究发现还有调节细胞生长、分化,抗癌,抗炎等作用。目前检测内源性地高辛样物质的方法很多,因方法学的差异,在灵敏度、特异性等方面各有长短。现多采用免疫测定法,将两种或两种以上方法优势互补、有机结合、综合利用,将是今后主要的发展趋势。Endogenous digoxin-like substances（EDLS）,which has very strong diuresis action and cardiac action,is secreted by human,it has biological activity like digoxin,more recent work implicates EDLS in the regulation of cell growth,differentiation,anti-cancer,anti-inflammatory and so on.Currently,EDLS can be detected in many ways,they are different in sensitivity,specificity because of methodological differences.Immunoassay is now widely used,put two or more methods together in order to complement each other＇s advantages will be the main development tendency.

关 键 词：内源性地高辛样物质 NA+-K+-ATP酶 免疫测定法 

分 类 号：R318[医药卫生—生物医学工程]