用末梢血检测糖化血红蛋白的临床应用分析  

Clinical application of glycosylated hemoglobin measurement of peripheral blood

作　　者：刘光明[1] 黄小兵[1] 陈世豪[1] 李健茹[1] 

机构地区：[1]南方医科大学附属新会医院检验科,广东江门529100

出　　处：《检验医学与临床》2010年第21期2313-2314,共2页Laboratory Medicine and Clinic

摘　　要：目的探讨用指端末梢血与用静脉血检测糖化血红蛋白(HbA1c)的结果的可比性以及用末梢血检测HbA1c在临床上的应用价值。方法 311例研究对象同时取末梢血与静脉血,用PDQPLUS全自动HbA1c分析仪检测HbA1c,对检测结果进行统计学分析。对其中127例2型糖尿病(T2DM)患者的末梢血HbA1c结果做血糖控制水平分析。对15例T2DM患者在全天不同时间段取末梢血检测HbA1c,与早晨空腹时结果作对比分析。结果用指端末梢血与用静脉全血检测HbA1c的结果相关性显著(r=0.9888,Y=0.122+0.977X),差异无统计学意义(P=0.12)。127例T2DM患者的血糖控制水平有27.6%控制理想,32.3%控制一般,40.1%控制效果差。同一天不同时间段用末梢血做HbA1c检测的结果与早晨空腹的结果比较差异无统计学意义(P=0.27、P=0.36、P=0.33、P=0.22、P=0.24、P=0.42)。结论用末梢血可以代替静脉全血检测HbA1c用于糖尿病的筛查、诊断和监控。Objective To investigate the results of glycosylated hemoglobin（HbA1c） measured with the peripheral blood and the venous whole blood,as well as the value of the detection of peripheral blood of HbA1c in the clinical application.Methods The peripheral blood and venous whole blood were taken from 311 cases of the subjects at the same time,using the PDQ PLUS HbA1c analyzer to detect the value of HbA1c of these two sets,and the results were compared by analyzed correlativity and paired t test.We used the results of peripheral blood HbA1c of 127 cases of Type 2diabetes to analyze the level of blood glucose control.The HbA1c of 15 patients with diabetes were detected by peripheral blood at different time throughout the day and the results were analyzed and valued immidiatly.Results The value of HbA1c of finger peripheral blood was significantly related to that of the venous whole blood.（r=0.988 8,P〈0.01,Y=0.122＋0.977 X） ,but the difference was of no significance.（P=0.12） .Among the totally 127cases of Type 2diabetes,blood glucose of 35 cases were controlled very ideally（27.6%） ,41 cases were controlled well（32.3%） ,but 51 patients were not controlled ideally（40.1%） .No significant differences were noticed in the value of HbA1c of peripheral blood in the patients treated at different time throughout the day,compared with those treated with fasting（P=0.27,P=0.36,P=0.33,P=0.22,P=0.24,P=0.42） .Conclusion The value of HbA1c was determined by peripheral blood,which can be used,instead of venous whole blood,to the screening,diagnose and monitor of the patients with diabetes.

关 键 词：糖化血红蛋白 末梢血 静脉血 糖尿病 

分 类 号：R446.11[医药卫生—诊断学]