抗病毒治疗对AIDS/TB和AIDS/TB/HCV患者CD4^+ T细胞及ALT的影响  

The influence of HAART on CD4^+ T cells and ALT levels of AIDS/TB and AIDS/TB/HCV patients

作　　者：蒙江明[1] 张云辉[2] 李军[2] 吴锋耀[1] 兰江[1] 

机构地区：[1]广西南宁市第四人民医院,南宁市530023 [2]解放军第三○二医院,北京市100039

出　　处：《内科》2010年第5期457-459,共3页Internal Medicine

基　　金：全球基金中国艾滋病项目(CHN-304-G03-H);南宁市科学研究与技术开发计划项目(200901014C)

摘　　要：目的探讨高效抗逆转录病毒治疗(Highly active antiretroviral therapy,HAART)对AIDS/TB和AIDS/TB/HCV患者CD4+T细胞及ALT的影响,以提高对AIDS/TB/HCV合并感染患者的治疗水平。方法对43例AIDS/TB,16例AIDS/TB/HCV患者实施HAART方案,分析比较两组治疗前后的CD4+ T细胞数及ALT水平的变化情况。结果经1年的HAART方案治疗后两组CD4+ T细胞均增加,与治疗前比较差异有统计学意义(P<0.05),但两组比较差异无统计学意义(P>0.05);治疗后两组ALT水平均增高,AIDS/TB/HCV组增加幅度大于AIDS/TB组,差异有统计学意义(P<0.05)。结论抗病毒治疗对AIDS/TB和AIDS/TB/HCV组都有效,两组间的治疗效果差别不大;抗病毒治疗对AIDS/TB/HCV患者肝功能损害大,但在使用护肝药物后近期是能耐受,远期治疗效果和对肝功能的影响需进一步观察。Objective To explore the influence of HAART on CD4＋ T cells and ALT levels of AIDS/TB and AIDS/TB/HCV infected patients,aimed to improve the therapeutic technology.Methods HAART was carried out in 43 cases AIDS/TB and 16 cases AIDS/TB/HCV infected patients,then compared the changes of CD4＋T cells and ALT levels before and after Treatment.Results After 1 year of HAART treatment,CD4＋ T cells had increased significantly（P0.05） in both groups compared with pretreatment,but the effect between the 2 groups hadn′t significant difference（P0.05）;ALT of the two infected groups were increased,the increase was more obvious in AIDS/TB/HCV patients then AIDS/TB patients（P0.05）;Conclusion HAART are effective in both groups,but there hadn＇t significant difference between AIDS/TB/HCV and AIDS/TB patients;HAART created more severe liver damage in AIDS/TB/HCV patients than AIDS/TB,but patients can endure a short-term liver damage under the protect of hepatoprotective,further observation are still needed to identify long-term therapeutic effect and impact on liver function of HAART.

关 键 词：艾滋病 结核病 丙型肝炎 CD4+ T细胞 

分 类 号：R512.91[医药卫生—内科学]