补气与理气中药对慢性缺氧小鼠能量代谢的作用  

An Approach to the QiInvigorating and QiRegulating Roles of Herbal Medicines on Energy Metabolism of Chronic Hypoxic Mice

作　　者：李兴泰[1,2] 张家俊[1,2] 陈文为 堀口贞次郎[1,2] 江崎宣久 

机构地区：[1]北京中医药大学中心实验室 [2]日本养命酒制造公司中央研究所

出　　处：《北京中医药大学学报》1999年第3期32-35,共4页Journal of Beijing University of Traditional Chinese Medicine

基　　金：教育部博士学科点专项科研基金;日本养命酒制造公司中央研究所资助

摘　　要：从能量的生成、储存和调节３个途径探讨配伍方剂常用的补气药（人参、黄芪、党参、白术）与理气药（枳实、厚朴、青皮、乌药）的作用。实验发现：①能量的生成：补气药人参、黄芪可降低耗氧速度与呼吸控制率，而党参、白术的作用不明显，理气药总的趋势是升高耗氧速度与呼吸控制率；②能量的储存：补气与理气药均显著升高肌酸激酶活力，而理气药又明显高于补气药；③能量的调节：补气药均可增加肝细胞能荷值。The roles of qiinvigorating herbal medicine (QIHM) and qiregulating herbal medicine (QRHM), widely used in prescriptions, are discussed from the perspectives of production, storage and regulation of ATP. QIHM include Renshen(ginseng), Huangqi(Astragalus), Dangshen(Codonopsis) and Baizhu(white atractylodes rhizome); QRHM include Zhishi(immature bitter orange), Houpo(magnolia bark), Qingpi(green tangerine) and Wuyao(lindra root). The results show: 1. In the energy production, Renshen and Huangqi can decrease oxygenconsuming rate(S3) and respiratory control ratio(RCR), but Dangshen and Baizhu haven't obvious effects on them; QRHM tend to increase S3 and RCR generally. 2. In the energy storage, both QIHM and QRHM can stimulate activity of creatine kinase(CK) significantly, and QRHM is stronger than QIHM. 3. In the regulation of energy, all the four QIHM can increase the energy charge (EC); on the contrary, all the four QRHM can decrease the EC of liver cells.

关 键 词：补气药 理气药 缺氧 能量代谢 中药 实验研究 

分 类 号：R285.5[医药卫生—中药学]