防风多糖增强巨噬细胞抗肿瘤作用的实验研究  

Effect of Polysaccharide of Radix Sileris on Enhancing MacrophagocytesAntineoplastic Function

作　　者：李莉[1] 周勇[1] 张丽[1] 陆蕴如[1] 王旭丹[1] 葛东宇[1] 邓巧虹[1] 

机构地区：[1]北京中医药大学

出　　处：《北京中医药大学学报》1999年第3期38-40,共3页Journal of Beijing University of Traditional Chinese Medicine

基　　金：卫生部科研基金

摘　　要：观察了防风多糖体内对Ｓ１８０移植瘤生长的影响，以及对Ｓ１８０瘤细胞免疫小鼠腹腔巨噬细胞（Ｍφ）吞噬活性的影响；同时，将Ｓ１８０瘤免疫小鼠腹腔Ｍφ再与Ｓ１８０瘤细胞混合后接种给小鼠，观察防风多糖对该Ｍφ直接抗肿瘤活性的影响。进一步用硅胶体内阻断Ｍφ功能，观察对防风多糖体内抗肿瘤效果的影响。结果表明，防风多糖体内应用能明显抑制Ｓ１８０实体瘤的生长（抑瘤率为５２９２％），提高Ｓ１８０瘤免疫小鼠腹腔Ｍφ的吞噬活性（Ｐ＜０．０１），并能提高Ｓ１８０瘤免疫小鼠腹腔Ｍφ与Ｓ１８０瘤细胞混合接种时的抗肿瘤活性（Ｐ＜０．０１）；但是，用硅胶阻断Ｍφ机能后，防风多糖的抗肿瘤作用大大下降，抑瘤率由５２９２％降到１１８２％。Observe the effect of polysaccharide of radix sileris (PRS) on the growth of S180 transplantation tumor in vivo, and celiac macrophagocytic activity of S180 oncocyte immunized mice. At the same time, combining the S180 oncocyte again with celiac macrophagocyte (M) of the immunized mice, vaccinate the mice and observe the effect of PRS on the M direct antineoplastic activity. Further, blocking the function of M by silica gel, observe the effect on antineoplastic function of PRS in vivo. The results show that PRS in vivo can obviously inhibit S180 tumor growth(inhibitory rate: 52.92%), increase the celiac M activity of S180 oncocyte immunized mice(P<0.01) and increase the antineoplastic activity when vaccinated with the combined S180 oncocyte and celiac M of the immunized mice(P<0.01). But, after M function blocked by silica gel, the antineoplastic function of PRS was greatly decreased, whose tumor inhibitory rate decreased from 52.92% to 11.82%. It indicated that the antineoplastic function

关 键 词：防风多糖 抗肿瘤作用 巨噬细胞 实验研究 

分 类 号：R285.5[医药卫生—中药学] R286.91[医药卫生—中医学]