慢性阻塞性肺疾病急性发作期痰白介素-8及白介素-16的检测及意义  

Detection and significance of interleukin-8 and interleukin-16 in induced sputum from acute chronic obstructive pulmonary disease

作　　者：吴聪[1] 柳广南[1] 钟小宁[1] 李超乾[1] 邓静敏[1] 施焕中[1] 

机构地区：[1]广西医科大学第一附院呼吸内科

出　　处：《广西医学》1999年第3期380-383,共4页Guangxi Medical Journal

摘　　要：目的：探讨白细胞介素－８（ＩＬ－８）及白细胞介素－１６（ＩＬ－１６）在慢性阻塞性肺疾病（ＣＯＰＤ）气道炎症中的作用。方法：采用酶联免疫吸附法（ＥＬＩＳＡ）检测收集到的ＣＯＰＤ患者急性发作期及正常人的痰ＩＬ－８及ＩＬ－１６水平。结果：ＣＯＰＤ患者急性发作期痰ＩＬ－８及ＩＬ－１６水平明显高于正常对照组的水平（Ｐ＜０．０５），ＣＯＰＤ患者痰液ＩＬ－８与ＦＥＶ１呈负相关（ｒ＝－０．６７，Ｐ＜０．０１），其痰ＩＬ－１６亦与ＦＥＶ１呈负相关（ｒ＝－０．４５，Ｐ＜０．０５）。结论：ＣＯＰＤ患者痰液ＩＬ－８及ＩＬ－１６均参与了ＣＯＰＤ的发病过程，而且以ＩＬ－８所起的作用最为主要。Objective:To explore the role of IL-8 and IL-16 in the airway inflammation of chronic obstructive pulmonary disease(COPD)Method:IL-8 and IL-16 of induced sputum in some patients with acute COPD and health controls were detected by ELISA methodResult:IL-8 and IL-16 of induced sputum in patients with acute COPD were much higher than those in health controlsIn addition,there was more inverse correlation between IL-8 of induced sputum and FEV1 in patients with COPD(r=-067,P<001),there was also the same correlation between IL-16 of induced sputum and FEV1(r=045,P<005)Conclusion;IL-8 and IL-16 might play important roles in the airway inflammation of COPD,and IL-8 appeared more important in them

关 键 词：阻塞性肺疾病 COPD 急性发作期 痰 IL-8 IL-16 

分 类 号：R563.04[医药卫生—呼吸系统]