C反应蛋白及白细胞计数与2型糖尿病下肢血管病变的关系研究  

The Relationship between C-reactive Protein and White Blood Count and Diabetes II Extremitas Inferior Vascular Lesion

作　　者：王春香[1] 陈建莉[1] 蒙华[1] 

机构地区：[1]新疆石河子市人民医院干部病房,832000

出　　处：《中国全科医学》2010年第29期3259-3261,共3页Chinese General Practice

摘　　要：目的观察2型糖尿病患者踝肱指数(ABI)与血清C反应蛋白(CRP)、白细胞计数(WBC)之间的关系。方法测定206例2型糖尿病患者的ABI,并将其分为低ABI组(ABI≤0.90,n=43)、正常ABI组(0.90<ABI<1.40,n=148)及高ABI组(ABI≥1.40,n=15)。检测患者CRP水平、WBC等指标,分析ABI与各指标间的关系。结果 (1)低ABI组、正常ABI组及高ABI组患者的CRP水平分别为(15.1±5.2)mg/L、(8.7±4.8)mg/L和(10.6±5.8)mg/L,WBC分别为(7.58±2.20)×109/L、(6.07±1.67)×109/L和(6.24±1.49)×109/L。3组患者CRP水平及WBC间差异均有统计学意义(F值分别为4.14和3.99,P<0.01);低ABI组患者的CRP水平及WBC显著高于正常ABI组和高ABI组,差异有统计学意义(P<0.01)。(2)在ABI<1.40的患者中,单因素Pearson相关分析显示,ABI与年龄(r=-0.157)、病程(r=-0.152)、UA(r=-0.103)、WBC(r=-0.162)、HbA1c(r=-0.174)、CRP(r=-0.193)、LDL-C(r=-0.214)均呈负相关(P<0.05)。多元逐步回归分析显示,LDL-C、CRP、HbA1c、WBC与ABI呈负相关(P<0.05)。(3)高ABI组患者的年龄及ln(尿清蛋白/肌酐)显著高于正常ABI组,差异有统计学意义(P<0.01)。结论在ABI<1.40的糖尿病患者中,ABI与CRP水平及WBC呈负相关;CRP及白细胞可能参与了糖尿病下肢血管病变的发生、发展;高ABI的意义及其危险性值得进一步研究,应予以重视。Objective To observe the relationship between ABI（ankle-brachial index） blood serum C-reactive protein（CRP） and white blood count（WBC） in patients with diabetes Ⅱ.Methods ABI of 206 patients with diabetes Ⅱ were detected,and were divided into lower ABI group（ABI≤0.90,n=43）、normal ABI group（0.90ABI1.40,n=148）and higher ABI group（ABI≥1.40,n=15）.Meanwhile the indexes of CRP and WBC were detected,and their relationship was analyzed.Results（1）The CRP level（mg/L） of the three groups of lower ABI,normal ABI and higher ABI were（15.1±5.2）,（8.7±4.8）,（10.6±5.8） respectively.The WBC of the three groups were（7.58±2.20）×109/L,（6.07±1.67）×109/L,（6.24±1.49）×109/L respectively.The difference in the level of CRP and WBC was significant（F=4.14,3.99,P0.01）.The levels of CRP and WBC in lower ABI group were significantly higher than that of the normal ABI group（t=0.21,0.32） and higher ABI group（t=0.27,0.40）（P〈0.01）.（2）Among patients with ABI 1.40,ABI had a negative correlation with age（r=-0.157）,course of disease（r=-0.152）,UA（r=-0.103）,WBC（r=-0.162）,HbA1c（r=-0.174）,CRP（r=-0.193） and LDL-C（r=-0.214） according to mono-factor Pearson correlation analysis.And according to gradual multiple regression analysis,ABI was negatively correlated with LDL-C,CRP,HbA1c,and WBC.（3） The ages and ln（UAlb/Cr）of higher ABI group were obviously higher than that of the normal ABI group,the difference was significance（P〈0.01）.Conclusion（1）Among the patients with ABI 〈1.40,ABI is negatively correlated with CRP and WBC.CRP and WBC may be involved in the occurrence and development of extremitas inferior vascular lesion in diabetes Ⅱ.（2）The significance and chanciness of high ABI is worth further research and emphasis.

关 键 词：糖尿病 2型 C反应蛋白 白细胞计数 糖尿病血管病变 踝肱指数 

分 类 号：R587.23[医药卫生—内分泌]