经纤维支气管镜导管介入治疗社区获得性重症肺炎  

Bronchofiberoscope and catheter intervention in treatment for Severe community-acquired pneumonia

作　　者：张耀亭[1] 殷建团[1] 杨松[1] 林素梅[1] 谢婷[1] 刘武胜[1] 

机构地区：[1]解放军第一七五医院呼吸结核科,福建漳州363000

出　　处：《临床肺科杂志》2010年第12期1725-1727,共3页Journal of Clinical Pulmonary Medicine

基　　金：南京军区科研基金课题(2008MA080)

摘　　要：目的探讨经纤维支气管镜导管介入病灶灌注对社区获得性重症肺炎的疗效及安全性。方法采用随机开放对照研究,共入选患者126例,其中介入组(常规治疗加导管介入)及对照组(常规治疗)各63例。常规治疗为头孢哌酮/舒巴坦3g静滴,q12h,左氧氟沙星400mg静滴,qd,共7～10天。介入治疗在常规治疗基础上经纤维支气管镜导管插入病灶肺段支气管,灌注左氧氟沙星300mg,qd,共4次。比较两组的临床和细菌学疗效及不良反应。结果介入组临床有效率90.5%,细菌清除率90.2%,对照组分别为74.6及72.9%(P均<0.05)。介入组和对照组不良反应发生率分别为6.3%及4.8%(P>0.05)。结论经纤维支气管镜导管介入肺灌注对社区获得性重症肺炎的疗效优于常规治疗,无明显不良反应及毒副作用。Objective To investigate the efficacy and safety of the Bronchofiberoscope and catheter intervention in treatment for Severe community-acquired pneumonia.Methods Sixty-three patients were treated by injecting levofloxacin through bronchofiberoscope and catheter in addition to conventional therapy,while sixty-three controls were treated by conventional therapy（cefoperazone/sulbactam 3.0 bid and levofloxacin 400mg qd） only,the treatment course is 7 ～ 10 days.Compare the clinical and bacteriological efficacy and adverse reactions of two groups.Results The clinical efficacy of interventional group is 90.5%,the rates of bacterial clearance is 90.2%,The control group is 74.6% and 72.9% respectively（P 0.05）.The rates of adverse reactions is 6.3% and 4.8% respectively（P 0.05）.Conclusions The efficacy of bronchofiberoscope and catheter intervention in the treatment for Severe community-acquired pneumonia in addition to conventional therapy is better than only conventional therapy,and has no significant adverse reactions and side effects.

关 键 词：重症肺炎 介入治疗 导管插入术 灌注治疗 

分 类 号：R563.1[医药卫生—呼吸系统]