肿瘤坏死因子-α、白介素-1、-6和-8在大鼠暴发性急性胰腺炎中的变化  

Changes of Tumor Necrosis Factor-α、Interleukin-1、-6 and -8 in Fulminate Acute Pancreatitis of Rats

作　　者：刘超[1,2] 张明仪[2] 文军[3] 郑重[2] 沈文律[3] 

机构地区：[1]汕头大学医学院,广东汕头515041 [2]广州医学院附属广佛医院普外科,广东佛山528251 [3]汕头大学医学院第二附属医院普外科,广东汕头515041

出　　处：《汕头大学医学院学报》2010年第3期142-144,共3页Journal of Shantou University Medical College

摘　　要：目的:探讨血清肿瘤坏死因子-α(TNF-α)、白介素(IL)-1、-6和-8在大鼠暴发性急性胰腺炎(FAP)中的作用。方法:建立大鼠FAP模型,检测各时点(0、6、12、24、48、72和120 h)胰腺组织病理评分(PM)和干湿重比率以及血清TNF-α、IL-1、-6和-8的变化。结果:实验组PM和干湿重比率在造模后6 h起各时点均与对照组比有统计学意义(P<0.01);血清IL-1水平6 h开始升高并达高峰,以后逐渐降至正常水平;TNF-α水平变化呈双峰型升高;IL-6和-8均在24 h升高并达高峰,其后逐渐降至正常水平。结论:大鼠FAP中TNF-α、IL-1(始动因子)、-6和-8水平皆升高。Objective： To explore the roles of tumor necrosis factor（TNF）-α, interleukin（IL）-1, -6 and -8 in FAP of rats. Methods： FAP models of rats were established. The changes of TNF-α, IL-1, -6 and -8 in serum were determined at all time points（0, 6, 12, 24, 48, 72 and 120 hours）. PM and dry and wet ratio were analyzed. Results： There was significant difference between two groups on PM and dry and wet ratio from all time points（ P 〈 0.01）. Serum IL-I increased and peaked at 6 hours, and decreased to normal level gradually. The level of serum TNF-α was bimodal pattern increase. IL-6 and -8 both increased and peaked at 24 hours, then decreased to nomml level gradually. Conclusion： In rat FAP models, the levels of TNF-α, IL-1（initiator）, -6 and -8 increase.

关 键 词：肿瘤坏死因子-Α 白介素-1 白介素-6 白介素-8 暴发性胰腺炎 大鼠 

分 类 号：R657.51[医药卫生—外科学]