对药品不良反应伤害量化分级评分标准的研究  

Study on criteria for quantitative classification of adverse drug reaction injuries

作　　者：黄登笑[1,2] 黄淇敏[2] 

机构地区：[1]上海交通大学安泰经济与管理学院,上海200043 [2]上海交通大学医学院附属第三人民医院医务部,上海201900

出　　处：《药学服务与研究》2010年第5期354-356,共3页Pharmaceutical Care and Research

基　　金：上海市教育委员会资助项目(No.09YS109);上海市宝山区科学技术委员会基金立项课题(No.08-E-2)

摘　　要：目的:设计一个简单易行的药品不良反应(ADR)伤害程度量化分级评分标准,为构建ADR补偿体系服务。方法:遴选部分专家,对不同器官和不同层级的ADR伤害进行评分。ADR伤害由重到轻初步分为1～10级,1级为最严重伤害,10级为最轻微伤害,根据评分结果进行统计分级。结果:ADR损害评分如下。极轻度伤害:>8.20分,轻度伤害:7.05～8.20分,中度伤害:4.31～7.04分,重度伤害:2.79～4.30分,极重度伤害:≤2.78,死亡单独作为一级。结论:这一分级方法可行,可以为进一步的ADR伤害量化研究提供借鉴。Objective：To establish a simple and practical criteria for quantitative classification of adverse drug reaction（ADR） injuries and provide reference for construction of the ADR compensation system.Methods：Some experts were invited to evaluate the degrees of ADR injuries to different organs and systems.Grade 1 to 10 were used for various degrees of severity of injury.Grade-1 implied death and grade-10 implied the slightest injury.The classification criteria were established according to the scores.Results：The ADR injuries were ranked into 6 levels.The score criteria for extremely slight,slight,moderate,severe and extremely severe injuries were8.20,7.05-8.20,4.31-7.04,2.79-4.30 and ≤2.78,respectively,and death was another level alone.Conclusion：The classification criteria are feasible and useful for further study.

关 键 词：药物副反应报告系统 伤害 量化分级 

分 类 号：R994.15[医药卫生—毒理学]