高原寒区战时肢体枪弹伤对机体肝酶谱和肾功能的影响  

Effects of gunshot wounds in swine's hind limbs on liver zymogram and renal function in a wartime environment at high altitude

作　　者：李素芝[1] 殷作明[1] 胡德耀[2] 林秀来[1] 石泉贵[1] 叶峰[1] 宋俊[1] 杨志焕[2] 何代平[1] 李楠[1] 何蓉城[1] 孙克勤[1] 刘安[1] 

机构地区：[1]西藏军区总医院全军高原战创伤救治中心,拉萨850003 [2]第三军医大学大坪医院野战外科研究所

出　　处：《西南国防医药》2010年第11期1173-1176,共4页Medical Journal of National Defending Forces in Southwest China

基　　金：军队指令性课题资助项目(01L008)

摘　　要：目的探讨高原寒区战时肢体枪弹伤对肝酶谱和肾功能的影响。方法将24只实验猪随机分为高原战时致伤组(GZ)、高原平时致伤组(GP)和平原平时致伤组(PP),分别于伤前、伤后不同时相点采静脉血,测定ALT、γ-GT、LDH和Cr、BUN含量。结果 (1)PP组在伤后早期ALT、γ-GT、LDH均有一个轻度升高,GP组在伤后ALT、γ-GT、LDH变化与PP组基本一致,但变化的程度较重;而GZ组伤前肝酶谱有轻度改变,伤后改变的程度较GP组显著,而且持续的时间较长。(2)PP组动物伤后早期肾功能有轻度改变,2d基本恢复。GP组伤后肾功能改变与PP组基本一致,但改变的程度稍重。GZ组伤后肾功能改变显著重于GP组,而且出现的时间早、恢复时间晚。结论高原高寒地区战时环境肢体枪弹伤后,肝酶谱和肾功能异常出现早、程度重、持续时间长。Objective To investigate the effects of gunshot wounds in swine＇s hind limbs on liver zymogram and renal function in a wartime environment at high altitude.Methods 24 pigs were randomly divided into GZ group（n=8）,GP group （n=8） and PP group （n=8）.Pigs in GZ group were sent to high altitude （3670 m above sea level） from plain （351 m above sea level） and lived in a simulated wartime environment for 72 h until their hind limbs were wounded by gunshot.Animals in GP group were also sent to the same high altitude but lived in a normal environment for 2 w and then suffered from gunshot wounds,while those in PP group were fed under normal conditions at 16-22 ℃ in plain （351 m above sea level） and injured thereafter.Venous blood of each pig was collected at 30 min before injury and 2 h,6 h,12 h,1 d,2 d,3 d,5 d,7 d,10 d,14 d after gunshot for the measurement of ALT,γ -GT,LDH,Cr and BUN content.Results （1）ALT,γ -GT and LDH content in PP group decreased slightly early after injury.These three indexes had a similar but severer change in GP group.Liver zymogram in GZ group had a slight change before injury,but it changed more significantly and longer than that in GP group after injury,and the change lasted longer.（2）Renal function in PP group had a slight change early after injury and recovered in 2 d,while GP group had a similar but severer change.The change of renal function in GZ group was significantly severer than that in GP group,and it appeared early and recovered late.Conclusion In a wartime environment at high altitude,the abnormality of swine＇s liver zymogram and renal function after gunshot wounds in hind limbs occurs early,severely and continuously.

关 键 词：高原 枪弹伤 肝酶 肾功能 

分 类 号：R594.3[医药卫生—内科学]