我院2009年57例抗肿瘤药物不良反应报告分析  

Adverse drug reactions induced by anti-cancer agents:a report of 57 cases in our hospital in 2009

作　　者：王喆元[1] 吴洪斌[1] 凌云华[1] 卫英[1] 施辰[1] 翟青[1] 陆国椿[1] 

机构地区：[1]复旦大学附属肿瘤医院药剂科复旦大学上海医学院肿瘤学系,上海200032

出　　处：《上海医药》2010年第11期512-515,共4页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的:探讨各种因素对抗肿瘤药物不良反应发生的影响及特点,以减少抗肿瘤药物不良反应的发生。方法:采用回顾性分析方法,收集我院2009年门诊、住院患者的57例抗肿瘤药物不良反应报告,对抗肿瘤药物种类、涉及的系统/器官及性别、年龄进行统计分析。结果:女性患者居多,占64.91%;51～60岁患者居多,占52.63%;铂类药物引发的不良反应发生率最高,占47.37%,主要为恶心、呕吐和腹泻;所累及的系统中,消化系统所占比例最高,达21.67%。结论:应重视抗肿瘤药物不良反应的监测工作,做好不良反应的预防和处理。Objective：To analyze the influence of various factors on adverse drug reactions（ADR） induced by anti-cancer drugs and elucidate the characteristics of ADR,so as to reduce its incidence.Methods：Retrospective analysis method was used.Fifty-seven reports of ADR from the outpatients and inpatients in our hospital were collected and a statistical analysis on the clinical data including kinds of anti-cancer drugs,harmed systems or organs,sex and age of patients was made.Results：Anti-cancer drugs-induced ADR mainly occurred in female patients（64.91%） and 51-60 years old patients（52.63%）.The platinum-induced ADR had the highest incidence（47.37%）,which mainly included nausea,vomiting and diarrhea.ADR mainly affected gastrointestinal system（21.67%）.Conclusion：Great attention should be paid to the work of monitoring ADR induced by anti-cancer drugs and our best should be paid to prevent ADR.

关 键 词：抗肿瘤药 药物不良反应 分析 合理用药 

分 类 号：R979.1[医药卫生—药品]