AlCl_3催化三组分Mannich反应“一锅法”合成β-胺基酮衍生物  

AlCl_3 as Catalyst for One-pot Synthesis of β-amino Ketone Derivatives by Three-component Mannich Reaction

作　　者：严文君[1] 王丽[1] 李娜[1] 甘贤雪[1] 

机构地区：[1]宜宾学院化学与化工学院,四川宜宾644000

出　　处：《宜宾学院学报》2010年第6期68-70,共3页Journal of Yibin University

基　　金：宜宾学院青年基金项目(2008QJ33;2008QJ30)

摘　　要：在室温少量AlCl3催化下,芳香醛、芳香酮和芳香胺可以顺利发生Mannich反应,三组分＂一锅＂合成了7个相应的β-胺基酮衍生物,产率69%-90%,克服了当前一些方法强质子酸或昂贵催化剂的使用.所有Mannich碱的结构均经熔点、IR、1H NMR证实.Mannich reaction of aromatic aldehydes,aromatic ketones and aromatic amines accoured with small amount of AlCl3 catalyst at room temperature.The three-component ＂one-pot＂ reaction compounds corresponding 7 β-amino ketone derivatives with a yield rate of 69% ~ 90%,which avoids the use of strong proton acids or expensive catalysts.The structure of these 7 derivatives was confirmed by melting point,IR and 1H NMR respectively.

关 键 词：ALCL3 MANNICH反应 芳香醛 芳香胺 β-胺基酮衍生物 

分 类 号：TQ246.36[化学工程—有机化工]