汉防己甲素对兔PRK术后房水TGF-β1的影响  

Effects of tetrandrine on TGF-β1 in aqueous humor after PRK in rabbits

作　　者：陶丹[1] 杜之渝[2] 

机构地区：[1]云南省第一人民医院,650031 [2]重庆医科大学附二院

出　　处：《中国医学创新》2010年第31期19-21,共3页Medical Innovation of China

摘　　要：目的 探讨汉避孕药已甲素抑制PRK术后角膜上及下雾状混浊形成的可能性.方法 健康新西兰大耳白兔60只,雌雄不限.随机分为汉防己甲素实验组（0.05%,0.1%,0.2%）,艾氟龙阳性对照组,生理盐水阴性对照组.于PRK术后1周,2周,1个月,2个月用ELISA法检测兔房水TGF-β1的表达.结果 PRK术后1周兔房水中TGF-β1含量开始升高,于术后2个月仍处于较高水平;汉防己甲素各浓度组房水TGF-β1含量均低于艾氟龙和生理盐水组,差异有显著性意义（P〈0.01）.结论 汉防己甲素可能是通过下调PRK术后TGF-β1的表达而发挥其对角膜上及下雾状混浊的抑制作用.Objective To discuss the inhibiting effects of tetrandrine on TGF - β1 in aqueous humor after PRK in rabbits and explore it,s mechanism. In order to find out a new drug which can replace eorticosteroid to treat haze after PRK. Methods Sixty rabbits were randomly distributed into five groups： Tet group （0.05% ,0. 1% ,0.2% ）, FMI, group, NS group. Haze was observed with Slit Lamp. Aqueous humor and coneal were obtained on the postoperalive 1 w,2 w,1 m,2 m. The content of TGF - β1 in aqueous hmuor were observed with ELISA. Results The content of TGF - β1 in aqueous humor were increased after PRK. The content of TGF-β1 in aqueous humor on Tet group was decreased than FML group and NS group（ P 〈0.01 ）. Conclusion Tetrandrine may exert it＇s inhibitive effect by releasing TGF - β1.

关 键 词：汉防己甲素 PRK术 TGF-Β1 

分 类 号：R541.75[医药卫生—心血管疾病]