2007～2008年某院住院初治肺结核耐药情况调查分析  

Investigation analysis on drug-tolerance of initial treatment pulmonary TB sufferers hospitalized from 2007 to 2008

作　　者：汪菊萍[1] 刘原杰 吴迪[1] 

机构地区：[1]重庆市公共卫生医疗救治中心,400039

出　　处：《重庆医学》2010年第21期2944-2945,共2页Chongqing medicine

摘　　要：目的通过对2007年12月至2008年12月住院初治肺结核药敏结果分析,调查初治肺结核患者对结核药物的耐药情况,从而获得初治肺结核患者的耐药趋势,指导临床合理用药。方法对102例初治肺结核患者药敏结果进行回顾性调查分析。结果 102例患者中,全部敏感56例,耐药者46例,总耐药率为45.1%。耐单药率以利福平(RFP)、利福喷汀(RFT)、链霉素(SM)、异烟肼(INH)4种药物较高,耐左氧氟沙星(LFX)率有增高趋势。耐多药率以利福平+链霉素(RS)、利福平+异烟肼(RH)、利福平+链霉素+异烟肼(SRH)、链霉素+利福平+乙胺丁醇(RSE)、链霉素+利福平+异烟肼+乙胺丁醇(SHRE)组合较高。结论结果显示初治肺结核的总耐药率有增高趋势,耐药性的发生更趋向于对主要一线药物的耐药和对多种药物耐药,对左氧氟沙星也出现耐药。因此,对结核病的临床治疗和管理应给予足够的重视。Objective Based on pulmonary tuberculosis drug-tolerance for initial treatment TB sufferers hospitalized from 2007 to 2008,to acquire the trend of drug-resistance of new TB sufferers and find better clinical treatment.Methods To adopt retrospective analysis on 102 cases of initial treatment pulmonary TB sufferers′ drug-tolerance.Results Among 102 cases,56 were sensitive,46 were drug-tolerant,accounting for 45.1%;single drug-resistance rates of rifampicin（RFP）,rifapentine（RFT）,streptomycin（SM） and isoniazide（INH） were relatively high,with increasing rate of levofloxacin（LFX） resistance;multi-drug resistance rates of RS（RFP＋SM）,RH（RFP＋INH）,SRH（RFP＋SM＋INH）,RSE（SM＋RFP＋ETB） and SHRE（SM＋RFP＋ETB＋INH） were relatively high.Conclusion The general drug resistance rate of new pulmonary TB sufferers is increasing,especially significant in clinical single and multi-drug treatment with no exception of LFX.Thus,importance should be attached to the clinical treatment and management of pulmonary tuberculosis.

关 键 词：肺结核 耐药性 

分 类 号：R521[医药卫生—内科学] R969.3[医药卫生—临床医学]