虎杖对实验性糖尿病大鼠血管内皮保护作用的观察  

Observation on the protection role of Huzhang on experimental vascular endothelial

作　　者：王芳[1] 褚伟[1] 祁友松[1] 

机构地区：[1]江汉大学医学院,湖北武汉430056

出　　处：《中医临床研究》2010年第19期21-23,共3页Clinical Journal Of Chinese Medicine

基　　金：湖北省自科基金面上项目2007ABA367

摘　　要：目的：探讨虎杖对糖尿病模型大鼠血管内皮保护作用的观察.方法：建立2型糖尿病大鼠模型,随机分为糖尿病模型组,虎杖高剂量组,虎杖低剂量组,二甲双胍组,另设空白正常对照组,观测其氧化应激水平.结果：与模型组比较,虎杖高低剂量组血栓素（TXB2）、内皮素（ET）降低,MDA水平降低,SOD水平升高,具有显著性差异;与二甲双胍组比较,无明显差异.结论：虎杖可降低血栓素（TXB2）、内皮素（ET）水平,增加SOD表达,降低MDA水平,对实验性糖尿病大鼠血管内皮有保护作用.Objective： To investigate observe on the protection role of Huzhang on experimental vascular endothelial. Methods： Establishing type 2 diabetic rat model, randomly divide into diabetic model group, Huzhang group, metformin group, other establidhing the control group, to observe the level of oxidative stress. Result： And compare of model group, Huzhang group the TXB2, ET was lower, level of MDA was lower, and the level of SOD was increased, has a significant difference; and compare of Metformin group, havn＇t significant difference. Conclusion： Huzhang on experimental vascular endothelial has protection role.

关 键 词：虎杖 糖尿病 血管内皮 氧化应激 

分 类 号：R587.1[医药卫生—内分泌]