阿维菌素在不同醇-水溶剂体系中溶解度的测定与关联  

Determination and Correlation of Solubilities of Avermectins in Different Systems of Alcohol-Water

作　　者：孙鹏[1,2] 刘俊果[1,2] 杨玉淮 刘琳[1,2] 

机构地区：[1]河北科技大学生物科学与工程学院,河北石家庄050018 [2]河北省发酵工程技术研究中心,河北石家庄050018 [3]河北宇泽化工科技有限公司,河北石家庄050035

出　　处：《高校化学工程学报》2010年第5期735-738,共4页Journal of Chemical Engineering of Chinese Universities

基　　金：河北科技大学科研基金资助课题

摘　　要：工业生产中阿维菌素在不同比例的有机溶剂-水体系中的溶解度是重要的基础数据,本实验采用平衡法测定了阿维菌素在甲醇含量100%～70%、乙醇含量100%～60%的水溶剂中,温度范围为30～70℃的溶解度,并采用多项式经验方程、半经验关联模型对实验测定溶解度数据进行关联,相关系数都在98%以上,结果较为满意。结果表明在甲醇-水溶剂体系中随水的比例增加,溶解度减少较为明显,以32℃时为例,90%甲醇-水溶剂比纯甲醇做溶剂的溶解度下降了67%,而乙醇-水体系随水的比例增加,溶解度减小较缓和,同样条件下,在95%乙醇-水溶剂中溶解度只下降了28%。The solubilities of avermectins in different alcohol-water systems are very important for the industrial production of avermectins.In this paper,the solubilities of avermectins in binary solvents of methanol-water（methanol content 100%～60%） and ethanol-water（ethanol content 100%～70%） were determined by equilibrium method in the temperature range of 30～70℃.The experimental results were correlated with mathematic model of empirical polynomial equation and the semiempirical equation,respectively,and both the correlation coefficients are above 98%.It was found that,in the binary solvent of methanol-water mixture,the higher the water content,the lower the avermectin solubility.At 32℃,the solubility of avermectin in 90% methanol-water mixture decreases by 67% of the solubility in absolute methanol.While the avermectin solubility in 95% ethanol-water mixture only decreases by 28% of the solubility in pure ethanol,this decrease is much lower than that in the methanol-water system.

关 键 词：阿维菌素 溶解度 关联 平衡法 

分 类 号：O645.2[理学—物理化学] R978.1[理学—化学]