体外受精-胚胎移植周期中卵巢反应不良患者受精方式的选择  

Clinical analysis of fertilization methods in IVF-ET cycles for patients with poor ovarian response

作　　者：郭新宇[1] 张金玉[1] 林德伟[1] 于妍[1] 葛明晓[1] 谢素嫣[1] 余梦娇[1] 

机构地区：[1]广州军区广州总医院妇产科辅助生育中心,广州510010

出　　处：《广东医学》2010年第16期2083-2085,共3页Guangdong Medical Journal

摘　　要：目的通过分析体外受精-胚胎移植周期中非男性因素的卵巢反应不良患者受精情况及临床结局,探讨这类患者合适的受精方式。方法回顾性分析体外受精-胚胎移植周期中获卵数≤4个周期共103个,按受精方式分为常规IVF组(46周期)与ICSI组(57周期),分析比较两组间受精率、正常受精率、卵裂率、受精失败发生率及临床妊娠率的差异。结果 IVF组受精率、正常受精率和卵裂率分别为78.8%、72.6%和95.1%,ICSI组受精率、正常受精率和卵裂率分别为72.0%、66.4%和96.8%,两组间差异无统计学意义(P>0.05);IVF组受精失败发生率为15.6%,高于ICSI组的1.8%(P<0.05);IVF组获卵周期妊娠率为27.3%,移植周期妊娠率为33.3%,均高于ICSI组的9.1%与11.1%(P<0.05)。结论对于无明确男性因素的卵巢低反应IVF周期,行IC-SI并不能提高其受精率和临床妊娠率。Objective To compare the efficacy of intracytoplasmic sperm injection（ICSI）and conventional IVF in patients with poor ovarian response.Methods One hundred and three in vitro fertilization-embryo transfer（IVF-ET）cycles from patients with poor ovarian response were classified into IVF group（46 cycles）and ICSI group（57 cycles）.Fertilization rate and normal fertilization rate,cleavage rate,incidence of fertilization failure,and clinical pregnancy rate were retrospectively analyzed in the two groups.Results The fertilization,normal fertilization and cleavage rates in conventional IVF group were 78.8%,72.6% and 95.1%,respective,and were 72.0%,66.4% and 96.8%,respectively,in ICSI group.No significant difference was observed between the two groups（P0.05）.Significantly higher incidence of fertilization failure was observed in IVF group compared with that in ICSI group（15.6% vs 1.8%,P0.05）.However,there were significantly higher clinical pregnancy rates per egg available and per embryo transfer cycle in IVF group.（27.3% vs 9.1% and 33.3% vs 11.1%,respectively,P0.05）.Conclusion ICSI treatment can not increase fertilization rate and clinical pregnancy rate in IVF-ET cycles in patients with poor ovaian response.

关 键 词：IVF-ET 卵巢反应不良 受精方式 

分 类 号：R711.6[医药卫生—妇产科学]