重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白与传统免疫抑制剂治疗强直性脊柱炎的临床对照研究  

Clinical control study of recombinant human tumor Necrosis Factor-Fc Fusion Protein and Traditional Immunity Depressant in treatment of ankylosing spondylitis(AS)

作　　者：陈慕芝[1,2] 照日格图[2] 王海云[2] 魏丽[1] 

机构地区：[1]新疆医科大学第一附属医院骨内科,新疆乌鲁木齐830000 [2]新疆医科大学附属中医医院风湿科,新疆乌鲁木齐830000

出　　处：《新疆医科大学学报》2010年第8期913-915,共3页Journal of Xinjiang Medical University

摘　　要：目的评价重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白(商品名:益赛普)治疗强直性脊柱炎(AS)的疗效。方法选取40例活动性强直性脊柱炎患者,随机分为2组,每组20例,分别用益赛普(25mg/次,1周2次)及柳氮磺吡啶(1.0g/次,1d2次)进行治疗,疗程12周,比较2种药在治疗后6、12周时疗效差别。结果益赛普组在治疗6、12周时的有效率分别为95%、95%,柳氮磺吡啶组的有效率分别为50%、70%,2组对比差异有统计学意义(P<0.05);益赛普组能明显缓解AS患者的腰背痛,缩短晨僵时间,减轻外周关节肿胀及外周关节压痛,且起效更快,其疗效明显优于柳氮磺吡啶组(P<0.05);益赛普组在缩短指地距及增加Schober试验距离方面也明显优于柳氮磺吡啶组(P<0.05),差异均有统计学意义;2组在枕墙距改善方面差异无统计学意义(P>0.05)。结论益赛普治疗强直性脊柱炎的疗效优于柳氮磺吡啶。Objective To evaluate the efficacy of Recombinant Human Tumor Necrosis Factor-Fc Fusion Protein （merchandise name： Etanercept） on Ankylosing Spondylitis （AS） compared with SSZ.Methods 40 cases of active ankylosing spondylitis were divided into two groups randomly （each group contains 20 cases）,using Etanercept （25 mg/times,two times for a week） and SSZ （1.0 g/times,two times for a day） respectively.The period of treatment was 12 weeks,then to compare the curative effect of two methods after 6 weeks and 12 weeks.Results The efficiency of Etanercept is 95% at the time points of 6 weeks and 12 weeks;while the efficiency of SSZ is 50% and 70%.There is the statistical difference between two groups （P0.05）.The Etanercept group obviously shouwn the posibility to alleviate the AS patient′s low-back-pain and shorten the time of morning ankylosis,ease the peri-arthritis swell and press-pain,and the curative effect of etanercept is better than SSZ （P0.05）.Moreover,the Etanercept group is also obviously better than the SSZ group in the aspects of shortenning distance from middle-finger to floor and increasing Schober test distance,there were significances in statistics （P0.05）.But in two groups there was no obvious difference in the aspects of improving the distance between occiput and wall （P0.05）.Conclusion The curative effect of etanercept for AS is better than SSZ.

关 键 词：益赛普 柳氮磺吡啶 强直性脊柱炎 

分 类 号：R593[医药卫生—内科学]