α-硫辛酸对臂踝脉搏波速度变化影响的干预研究  

Effect of oral alpha-lipoic acid in high risk cardiovascular on brachial-ankle pulse wave velocity:a intervention study

作　　者：张卫国[1] 李农 胡晓娟 黄永迪[1] 王倩[1] 王琛琛[1] 许睿伟[1] 严恺[1] 严卫丽[1] 

机构地区：[1]新疆医科大学公共卫生学院,新疆乌鲁木齐830011 [2]新疆克拉玛依市人民医院,新疆克拉玛依834000

出　　处：《新疆医科大学学报》2010年第9期1056-1059,共4页Journal of Xinjiang Medical University

摘　　要：目的观察心血管病高危人群口服抗氧化剂α-硫辛酸(alpha-lipoic acid,ALA)前后臂踝脉搏波速度(baPWV)变化,探讨ALA能否降低心血管危险因素及动脉硬化程度,为心血管病人群提供一级预防理论依据。方法采用随机、双盲、对照、交叉试验设计,在克拉玛依市人民医院体检中心按照研究对象入选和排除条件筛选出健康的20～60岁的汉族研究对象104例,经签署知情同意书后,测量身高、体重、腰围、臀围、血脂4项、baPWV。采用区组设计随机化的方法随机分为2组,分别接受为期8周ALA(1200mg/d)干预和安慰剂对照,洗脱4周后,2组交换再进行8周的干预。整个研究过程中保持双盲的设计。比较2次观察终点时干预组和安慰剂对照组间空腹血糖、空腹胰岛素、甘油三酯、总胆固醇、高密度胆固醇、动脉硬化程度等心血管和2型糖尿病危险因素或者心血管疾病相关早期敏感指标等连续变量平均水平的差别。结果按照意向分析(ITT)策略,104例均进入结果分析。干预组左右两侧baPWV前后差值分别为-2.80±11.6和-3.01±12.7,均低于安慰剂组左右两侧baPWV前后差值(分别0.57±12.71和0.28±12.83),口服ALA左右两侧baPWV差异有统计学意义(P<0.05)。结论口服ALA可降低动脉硬化的程度,对氧化应激引起的心血管疾病有一定的预防作用。Objective To observe the effect of oral ALA supplement on brachial-ankle pulse wave velocity（baPWV）in overweight subjects with risk of cardiovascular disease.Methods The 104study subjects,who meet the inclusion criteria by regular physical examination,were recruited from kelamayi people hospital during the May to October 2009.Inclusion criteria：Han ethnicity;20～60years old.BMI≥25kg/m2 and having one of the following risk factors：borderline hypertension（130mmHg≤SBP140mmHg and/or 85mmHg≤DBP90mmHg）,dyslipidemia（fasting total cholesterol≥5.2mmol or HDL-C 1.04mmol/L）,or impaired fasting glucose（fasting glucose level between 6.1and 7.0mmol/L）,subjects were excluded from the study if taking any antioxidant vitamin supplement.We randomly assigned the participants to Group 1or Group 2by gender.Group 1received 8-week oral ALA intervention（1 200mg/day）,while Group 2received placebo for 8weeks.After 4-week washout period,we crossed over the two groups and give the opposite intervention to each group for another 8weeks.Measurements included anthropometrics（weight,height,waist circumference and hip circumference）,baPWV,blood pressure,fasting glucose,lipids profile were examined four times at 4visits.Statistical analyses were performed by regular methods by ITT rule.Results According to intension to treat,all of relevant clinical data were analyzed by General Lineal Model.Compared with baPWV of placebo group,baPWV of the intervention group decrease coronary atherosclerosis（P0.05）.Conclusion Oral ALA supplement 1 200mg/d for 8 weeks decreases cardiovascular risk factors and coronary atherosclerosis,which shows the positive effect of ALA in prevention of the development of cardiovascular diseases and atherosclerosis.

关 键 词：臂踝脉搏波速度(baPWV) 心血管危险因素 动脉硬化 

分 类 号：R541.4[医药卫生—心血管疾病]