柯萨奇B组病毒感染与儿童相关疾病关系的研究  

Study on the relationship between Coxsackie B virus infection and some diseases in children

作　　者：阮强[1] 刘兰青[1] 吕绳敏[1] 刘庆[1] 吉耀华[1] 魏洪斌[1] 

机构地区：[1]中国医科大学第二临床学院病毒室

出　　处：《小儿急救医学》1999年第2期60-61,共2页Pediatric Emergency Medicine

摘　　要：目的探讨柯萨奇Ｂ组病毒感染与儿童急性白血病、过敏性紫癜、脊髓炎和川崎病等发生的关系。方法采用间接免疫荧光方法检测２５５例患儿血清和４７７例对照组血清柯萨奇Ｂ组病毒特异性ＩｇＭ抗体。结果３７例急性白血病患儿血清阳性率为１８９２％；７５例过敏性紫癜患儿血清阳性率为１０６７％；４１例脊髓炎患儿血清阳性率为１２２０％；５３例川崎病患儿血清阳性率为９４３％。４９例胰岛素依赖型糖尿病患儿血清阳性率为４０８％。４４７例对照组患儿血清阳性率为１３４％。除胰岛素依赖型糖尿病患儿外，其他实验组与对照组的检测结果经统计学分析，差异非常显著。结论柯萨奇Ｂ组病毒感染与儿童急性白血病、过敏性紫癜。Objective To understand the relationship between Coxsackie B virus infection and some diseases in children,such as acute leukemia(AL),anaphylactoid prupura(AP),myelitis(MY)and kawasaki disease(KD).Methods Indirect immunofluouescence assay was used to detect the specific IgM antibodies of Coxsackie B virus in 255 sera from patients and 447 sera from control group.Results The positive rate of coxsackie B virus in 447 sera form cotrol group was 1 34%;The positive rate in 37 sera from AL patients was 18 92%( P <0 01);The positive rate in 75 sera from AP patients was 10 67%( P <0 01);The positive rate in 41 sera from myelitis patients was 12 2%( P <0 01);The positive rate in 53 sera from KD patients was 9 43%( P <0 01);The positive rate in 49 sera from IDDM patients was 4 08%( P >0 05).Conclusion The infection of Coxsackie B virus was related to children acute leukemia,anaphylactoid purpura,myelitis and kawasaki disease..

关 键 词：柯萨奇B组病毒 急性白血病 过敏性紫癜 儿童 

分 类 号：R725.125[医药卫生—儿科] R733.710.2[医药卫生—临床医学]