低剂量X射线全身照射对小鼠脾细胞转铁蛋白受体表达的影响  

EFFECT OF WHOLE BODY IRRADIATION WITH LOW DOSE X-RAYS ON EXPRESSION OF TRANSFERRIN RECEPTOR IN SPLENOCYTES OF MICE

作　　者：罗灿[1] 苏旭[1] 刘建香[1] 付士波[1] 鞠桂芝[1] 

机构地区：[1]白求恩医科大学卫生部放射生物重点实验室

出　　处：《辐射研究与辐射工艺学报》1999年第2期97-100,共4页Journal of Radiation Research and Radiation Processing

基　　金：国家自然科学基金

摘　　要：采用直接免疫荧光流式细胞术方法，检测了低剂量Ｘ射线全身照射对小鼠脾脏淋巴细胞转铁蛋白受体（ＴｆＲ）表达的影响。结果表明，低剂量Ｘ射线全身照射可增强脾脏淋巴细胞ＴｆＲ的表达，由于ＴｆＲ是Ｔ淋巴细胞激活与增殖过程中表达在细胞表面的重要受体之一，与Ｔ淋巴细胞激活与增殖有着密切关系。所以上述结果可能是低剂量电离辐射增强机体免疫功能的又一证据，同时也说明ＴｆＲ在低剂量电离辐射免疫增强效应中起着重要作用。研究证实，Ｔ淋巴细胞激活与增殖是低剂量电离辐射增强机体免疫功能的中心环节。It has been demonstrated that the activation and proliferation of T lymphocytes is a crucial link in enhancing immune function by low dose ionizing radiation. Transferrin receptor(TfR) is one of the important membrane receptors expressed in T cells during activation and proliferation of T lymphocytes and is closely related with the activation and proliferation of T lymphocytes. TfR expression in lymphocytes in mouse spleens was examined using direct immunoflurescence and flow cytometric analysis. The results showed that whole body irradiation(WBI) with low dose X-rays could stimulate TfR expression in lymphocytes in mouse spleens, and this might be another evidence for enhancing immune function with low dose radiation and meanwhile indicated that TfRs play an important role in enhancing immune function with low dose radiation.

关 键 词：脾细胞 X射线 低剂量辐射 转铁蛋白受体 

分 类 号：R811.5[医药卫生—放射医学] Q691.5[医药卫生—临床医学]