同期供体骨髓干细胞输注有利肝移植受者术后早期恢复  

Simultaneous infusion of donor bone marrow stem cells promotes postoperative recovery in liver recipients

作　　者：江艺[1] 张小进[1] 吕立志[1] 杨芳[1] 蔡秋程[1] 潘凡[1] 

机构地区：[1]南京军区福州总医院肝胆病中心肝胆外科,福州350025

出　　处：《中华细胞与干细胞移植（电子版）》2009年第1期52-55,共4页

基　　金：南京军区医药卫生科研基金面上项目（08KA104）

摘　　要：目的探讨同期供体骨髓干细胞输注对肝脏移植受者术后早期恢复的影响。方法2008年3月至12月本中心30例肝移植受者分为两组,实验组8例,行同期供体骨髓干细胞联合肝脏移植;对照组22例,仅行肝脏移植,不行骨髓干细胞输注。观察两组受者术后免疫抑制剂用量、肝功能变化、急性排斥反应和感染并发症发生情况,以及术后住院时间和费用。结果实验组术后甲基强的松龙总用量和出院时每日他克莫司用量显著低于对照组[甲基强的松龙：（1314±105）mgvs（1884±256）mg,P〈0.01;他克莫司：（3.73±0.35）mg/dvs（4.93±0.62）mg/d,P〈0.01]。术后第1天、第3天实验组血清谷丙转氨酶、谷草转氨酶均显著低于对照组（P〈0.05）。结论同期供体骨髓干细胞联合肝脏移植可以降低术后免疫抑制剂用量,减轻术后早期肝脏损伤,不增加治疗风险,是一种安全有效的治疗方法。Objective To evaluate the clinical efficacy of donor stem cell infusion in the patients receving liver transplantation in the early postoperative period.Methods Eight patients in experimental group received simultaneous bone marrow stem cell infusion and liver transplantation,while 22 patients in control group were not given bone marrow stem cell infusion.Dosage of immunosuppressants,liver function,acute rejection,infection episode,length of stay（LOS）and cost were compared between the two groups.Results The postoperative dosage of Methylprednisolone and daily dosage of tacrolimus were both significantly lower in experimental group than those in control group[Methylprednisolone： （1314±105）mg vs（1884±256）mg,P0.01;FK506：（3.73±0.35）mg/d vs（4.93±0.62）mg/d, P0.01].Respectively,serum alanine aminotransferase and aspartate aminotransferase levelsin experimental group were remarkably lower than those in control group at 1 and 3 d after the operation（P0.05）.Conclusion As a safe and effective approach,infusion of donor bone marrow stem cell during liver transplantation could efficiently decrease the dosage of immunosuppressants,which alleviates early hepatic injury.

关 键 词：骨髓干细胞输注 肝脏移植 免疫抑制剂 排斥反应 

分 类 号：R656.8[医药卫生—外科学]