血培养中病原菌分布及药敏调查分析  

Distribution and resistance of pathogentic bacteria in blood culture

作　　者：王潭枫[1] 席云[1] 钟月桂[1] 

机构地区：[1]中山大学附属第三医院检验科,广东广州510630

出　　处：《中国微生态学杂志》2010年第10期918-921,共4页Chinese Journal of Microecology

基　　金：广州市科技计划项目(2006Zi-E0141)

摘　　要：目的了解血培养中病原菌的分布及药敏情况,供临床借鉴。方法对中山大学附属第三医院血培养标本中所分离到的细菌及药敏结果进行统计分析。结果从血培养标本中分离到细菌239株,其中其中革兰阴性杆菌(G-b)131株,占52.6%,革兰阳性球菌(G+c)99株,占39.8%(99/236),真菌占6.8%,大肠埃希菌和肺炎克雷伯菌产ESBLs菌检出率分别是54.2%和48.6%,只对亚胺培南、特治星和阿米卡星敏感,敏感率超过85%,G+c中,耐甲氧西林金黄色葡萄球菌(MRSA)和耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)的检出率分别是42.9%和89.2%,只对万古霉素敏感(100%),检出的肠球菌已出现对万古霉素耐药。结论血培养分离的病原菌分布复杂,产ESBLs菌和MRS菌株检出率高,临床应重视血培养检测结果.合理用药。Objective To investigate the distribution and drug resistance of pathogenic bacteria in blood culture in order to provide references for clinical antimicrobial drug usage reasonably. Method Blood samples from blood department in our hospital were cultured and used to detect the bacteria and drug sensitivity tests,then the results were analyzed statistically.Result The 239 strains of bacteria were isolated from samples of blood culture,131 strains（52.6%） gram-negative microbes and 99 strains（39.8%） gram-positive microbes and 9 strain（6.8%） fungi were among 239 strains.The positive rates of ESBLs in Escherichia coli and in K.pneumoniae were respectively 54.2%and 48.6%.They were only highly sensitive to imipenem,tazocin and amikacin and the sensitivity rates were over 85%.Among the G＋ c,the positive rates of MRSA and MRCNS were 42.9% and 89.2% respectively,and the pathogens were only sensitive to vancomycin and the sensitivity rates were reached 100%.But enterococci showed highly multiple drug resistance already.Conclusion The distribution of pathogenic bacteria in blood culture is complicated,and the positive rates of ESBLs and MRS are high.So the test results of blood culture should be seriously in clinical and are of great significance directing clinical chemotherapy.

关 键 词：血培养 病原菌 药敏试验 

分 类 号：R378[医药卫生—病原生物学]