HPV检测早期筛查宫颈癌的临床意义——附妇科门诊2761例宫颈拭子HPV分析  

Application of human papillomavirus testing for early cervical cancer screening

作　　者：杨安素[1] 涂权梅[1] 朱雪琼[1] 

机构地区：[1]温州医学院附属第二医院妇产科,浙江温州325027

出　　处：《中国微生态学杂志》2010年第10期938-939,941,共3页Chinese Journal of Microecology

摘　　要：目的探讨女性HPV DNA检测在宫颈癌防治方面的意义。方法应用DNA杂交技术对2 761例妇科门诊就诊者基因分型检测。结果 2 761例样本中,HPV感染有768例,阳性率27.82%,HPV感染人次972人次。检测高危型HPV（16,18,31,33,35,39,45,51,52,56,58,59,68）813人次,占感染总人次的83.64%;检出低危型HPV（6,11,42,43,44）73人次,占感染总人次7.51%;中国人群常见型HPV（53,66,CP8304）86人次,占感染总人次的8.85%。165例样本中包含了25种亚型的感染。结论 DNA杂交技术检测HPV基因分型,可一次检测多种亚型,有利于对HPV多重感染的诊断和宫颈癌的防治,可作为宫颈癌筛查的手段。Objective To investigate the distribution of human papillomavirus（HPV） genotype infections and explore the application of HPV DNA test in the prevention and treatment of cervix cancer.Method Totally 2 761 women were detected for HPV genotyping by using DNA hybridization technique.Result Of these 2 761 women,768 women（27.82%） were found to be HPV-positive.Among 972 cases of HPV infection 813（83.64%） were infected with high-risk HPV types（HPV-16,18,31,33,35,39,45,51,52,56,58,59,and 68）,73（7.51%） were with low-risk types（HPV-6,11,42,43,and 44）,and 86（8.85%） were with some common types（HPV-53,66,and P8304） among Chinese women.2～5 subtypes were detected in 165 patients.Conclusion DNA hybridization technique is useful for the diagnosis of multi-HPV infection and therefore for the prevention and treatment of cervical cancer.

关 键 词：宫颈癌 HPV分型 DNA杂交技术 

分 类 号：R711.74[医药卫生—妇产科学]