替米沙坦对高血压患者颈总动脉内膜中层厚度的影响  

Effect of Telmisartan on carotid arterial intima-media thickness in patients with essential hypertension

作　　者：郑东诞[1] 李玉杰[2] 陈宏武[1] 高修仁[1] 刘丽娟[1] 

机构地区：[1]中山大学附属第一医院心内科,广东省广州510080 [2]中山大学附属第一医院急诊科,广东省广州510080

出　　处：《中国基层医药》2010年第19期2593-2595,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：广东省自然科学基金（07001655）

摘　　要：目的 观察替米沙坦对高血压患者颈总动脉内膜中层厚度的影响.方法 选择104例轻、中度高血压病患者,随机分为替米沙坦组35例（服用替米沙坦80 mg/d）、雷米普利组35例（服用雷米普利5 mg/d）和对照组34例（使用其它降压药物）.治疗过程中监测血压,入选患者开始时和治疗12个月后测定颈总动脉内膜中层厚度（CIMT）.结果 完成12个月治疗者共91例：替米沙坦组33例,雷米普利组28例,对照组30例.替米沙坦组和雷米普利组在有效降低血压同时,CIMT明显减低（均P〈0.05）,与对照组CIMT差异无统计学意义;雷米普利引起干咳需要停用药物者5例.结论 替米沙坦能够有效降低血压并减低CIMT,雷米普利具有相似作用,但替米沙坦不良反应较少.Objective To investigate inhibitory effect of Telmisartan on carotid arterial intima-media thickness in patients with essential hypertension. Methods 104 patients with mild or mid essential hypertension were randomly divided into three groups, which include telmisartan group（ telmisartan 80 mg/d PO）, ramipril group（ ramipril 5 mg/d PO）, and control group（ other anti-hypertension agents）. Blood pressure was monitored during treatment. Carotid arterial intima-media thickness（CIMT） were measured in all patients at beginning and patients who had the 12 months course. Results There were 91 patients who had the 12 months course,which include telmisartan group33 cases,ramipril group28 cases, and control 30 cases. The CIMT was significantly decreased in telmisartan group and ramipril group （ all P 〈 0. 05 ）, and not changed in control while blood pressure fall effectively. In ramipril, group5 cases were ceased the course because of severe cough. Conclusion Both telmisartan and ramipril could decrease blood pressure and CIMT effectively, and there were less side effects in telmisartan group.

关 键 词：高血压 动脉内膜中层厚度 替米沙坦 雷米普利 

分 类 号：R544[医药卫生—心血管疾病]