三种不同方法治疗早产的疗效比较  

Comparison of clinical effect of three different methods in treatment of premature

作　　者：祁卫红[1] 陈京芳[1] 

机构地区：[1]南京医科大学附属南京市第一压院妇产科,江苏省南京210006

出　　处：《中国基层医药》2010年第20期2771-2772,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 比较三种不同配伍保胎药物治疗早产的临床疗效.方法 早产病例共150例,随机分为三组,即利托君组、硫酸镁联合沙丁胺醇组、硫酸镁组,观察各组治疗后孕妇的的宫缩抑制情况、起效时间、累计用药时间、延长孕期时间.结果 利托君组、硫酸镁联合沙丁胺醇组、硫酸镁组的成功率各为94%、78%、70%,利托君组明显优于联合组和硫酸镁组,显效时间分别为（2.16±0.91）h、（4.14±1.07）h、（5.12±1.45）h,三组间比较均有统计学意义（均P＜0.05）,累计用药时间分别为（7.04±1.16）d、（7.46±1.20）d、（7.06±2.78）d,三组间比较无统计学意义（均P＜0.05）;延长妊娠平均天数各为（22.08±7.32）d、（17.42±5.85）d、（11.82±5.04）d,三组间比较均有统计学意义（均P＜0.05）.结论 单独使用利托君及硫酸镁联合沙丁胺醇治疗早产明显优于硫酸镁单独使用组.Objective To compare the clinical effect of three different methods in treatment of premature.Methods 150 premature patients were randomly divided into three groups,50 cases for each group,received treatments with ritodrine,magnesium sulfate plus salbutamol,or magnesium sulfate alone respectively. The tensity of uterine contraction, the interval between drug administrations and the relief of uterine contraction, the accumulative drug using time, the elongated pregnancy durations were observed for the dertermination of effectiveness. Results The group treated with ritodrine, magnesium sulfate plus salbutamol or magnesium sulfate were effective in 94%, 78%,70% of patients of each group, and it showed that ritodrine was more effective than the combination and magnesium sulfate. The intervals of drug using and contraction relief were statistically different among three groups, （2. 16 ±0. 91）h,（4. 14 ± 1.07）h,（5.12 ± 1.45） h for each（all P ＜0.05）.The cumulative drug using times were（7. 04 ±1. 16） d, （7.46 ± 1.20） d, （7.06 ± 2.78） d for three groups and proved not to be statistically significant （ all P ＞0. 05 ）. The elongated pregnancy durations were （22.08 ± 7.32 ） d, （ 17.42 ± 5.85 ） d and （ 11.82 ± 5.04 ） d, and significantly different in three groups （ all P ＜ 0. 05 ）. Conclusion The treatment of premature with ritodrine or the combination of magnesium sulfate and salbutamol was superior to using magnesium sulfate alone.

关 键 词：利托君 硫酸镁 沙丁胺醇 早产 

分 类 号：R714[医药卫生—妇产科学]