新型佐剂狂犬病灭活疫苗的研制  

Development of Rabies Inactivated Vaccine with a New Type Adjuvant

作　　者：顿灿[1] 孙招金 薛素强 李敏 梁红茹[1] 王玉[1] 谢运冰[1] 张婧[1] 张东霞[1] 黄永亮[1] 郭霄峰[1] 

机构地区：[1]华南农业大学兽医学院,广州510642 [2]广州市华南农大生物药品有限公司,广州511300

出　　处：《中国兽药杂志》2010年第10期20-23,共4页Chinese Journal of Veterinary Drug

摘　　要：利用反向遗传操作系统拯救出狂犬病毒的携带双G基因的HEP-dG株,选用新型佐剂制成狂犬病灭活疫苗,进行小鼠免疫试验、比格犬最小免疫剂量试验、免疫持续期试验。试验表明,携带双G基因的HEP-dG株具有良好的免疫原性,该新型佐剂狂犬病灭活疫苗免疫效果较好,具有完全的保护力和较长的免疫保护持续期。Recombinant HEP-dG rabies virus stock was rescued by the technique of reverse genetics,inactivated rabies vaccines with a new type adjuvant for immune test were conducted in mice and the minimum immune dose test were conducted in beagle.The results demonstrated that recombinant HEP-dG rabies virus strain has good immunogenicity,and the rabies inactivated vaccines were effective and protective.

关 键 词：狂犬病灭活疫苗 佐剂 免疫试验 

分 类 号：S859.797[农业科学—临床兽医学]