杞菊地黄丸对血管紧张素Ⅱ诱导损伤的血管内皮细胞超微结构的影响  

Effect of Qijudihuang Pill on Vascular Endothelial Cells Injured by Angiotensin Ⅱ

作　　者：多芳芳[1] 邹志东[1] 王文娟[1] 丁相海[2] 张楠[1] 贾富霞[1] 

机构地区：[1]首都医科大学中医药学院,北京100069 [2]首都医科大学基础医学院,北京100069

出　　处：《中国医药导刊》2010年第10期1751-1752,1750,共3页Chinese Journal of Medicinal Guide

基　　金：课题资助项目;首都医科大学基础临床课题(NO.10JL19)

摘　　要：目的:观察杞菊地黄丸对血管紧张素Ⅱ(AngⅡ)诱导损伤的血管内皮细胞超微结构的影响。方法:采用AngⅡ诱导人脐静脉内皮细胞损伤为实验模型。分别设立正常对照组、AngⅡ损伤组、AngⅡ损伤+空白血清组、AngⅡ损伤+杞菊地黄丸血清组。采用电子显微镜观察细胞形态结构。结果:电子显微镜观察结果显示,AngⅡ损伤+杞菊地黄丸血清组血管内皮细胞超微结构损伤程度明显低于AngⅡ损伤组和AngⅡ损伤+空白血清组。结论:益肾中药杞菊地黄丸对高血压病血管内皮细胞损伤具有一定的保护作用。Objective：To observe the effect of Qijudihuang Pill on vascular endothelial cells injured by Angiotensin Ⅱ.Methods：The experiment model that human umbilical vein endothelial cells were injured by Angiotensin Ⅱ （Ang Ⅱ） was established. It was divided into four groups： normal control group, Ang Ⅱ injury group,Ang Ⅱ injury pluses blank blood serum group,Ang Ⅱ injury pluses Qijudihuang Pill blood serum group.The Cell Ultrastructure was observed by Transmission electron microscopy （TEM）.Results：The cells morphology ofAng Ⅱ injury pluses Qijudihuang Pill blood serum group were better than that of Ang Ⅱ injury group.Conclusion：Qijudihuang Pill can protect the vascular endothelial cells.

关 键 词：杞菊地黄丸 血管内皮细胞损伤 AngⅡ 高血压病 

分 类 号：R285.5[医药卫生—中药学]