二硫化碳职业暴露对男工性功能及其配偶生殖结局的影响  

Effect of Carbon Disulfide on Male Sexual Function and Reproductive Outcomes

作　　者：丁情[1] 季佳佳[1] 马纪英[1] 周义军[1] 黄晓彧[1] 王宁[1] 王松[2] 李学贵 陈国元[1] 

机构地区：[1]华中科技大学同济医学院公共卫生学院环境与健康教育部重点实验室,湖北武汉430030 [2]华中科技大学同济医学院公共卫生学院预防医学实验教学中心,湖北武汉430030 [3]新乡市职业病防治研究所,河南新乡453000

出　　处：《环境与职业医学》2010年第10期622-625,共4页Journal of Environmental and Occupational Medicine

基　　金：国家自然科学基金资助项目(编号:30471442;编号:30872091)

摘　　要：[目的]探讨CS2职业暴露对男工性功能及其配偶生殖结局的影响,为制定干预对策提供科学依据。[方法]对276名CS2暴露男工(其中仅男工暴露132人为单纯组,男工及其妻子均暴露144人为混合组)和126名非CS2暴露男工的基本情况、性功能及其配偶生殖结局进行回顾性队列研究。[结果]性功能调查结果显示,年龄<40岁或工龄≥10年的CS2暴露组男工性生活和谐及性生活频度降低,性生活厌恶增加(P<0.05);各组间男工妻子妊娠并发症差异无统计学意义(P>0.05)。生殖结局调查结果表明,混合组的自然流产率与单纯组、对照组比较具有统计学意义(P<0.05);混合组与对照组比较,子代低出生体重率较高(P<0.05),子代智力发育及体格发育差异无统计学意义(P>0.05)。[结论]长期、低浓度CS2暴露可明显影响男工性生活态度、频率并可能导致不良的生殖结局,但对子代的智力及体格发育影响不明显。[Objective] To investigate the sexual function and reproductive outcomes of male workers occupationally exposed to CS2,and to provid a scientific basis for interference.[Methods] In a retrospective study,the basic information, sexual function and reproductive outcomes of 276 workers exposed to CS2 were collected through a self-administered questionnaire, in which 132 male workers exposed to CS2 but their wives did not were set as single exposure group,144 male workers and their wives both exposed as mixed exposure group.Another 126 unexposed male workers set as control.[Results] The sexual function investigation showed that male workers in both exposure groups who aged under 40 and exposed more than 10 years had sexual unsatisfactory,decreased number of sex,and increased sex aversion（P0.05）.The rate of pregnancy complications of the wives in all groups had no statistical significance（P0.05）.The rate of spontaneous abortion in the mixed exposure group was significantly different from single exposure and control groups（P0.05）.The rate of low birth weight infants of the mixed exposure group had significant difference compared with the control group（P0.05）.Offsprings’intelligence and physical development had no significant difference in all groups（P0.05）.[Conclusion] A long term and low level of CS2 exposure had an effect on the attitude and frequency of sex life of male workers,and may result in bad reproductive outcomes as well.But there were no significant changes of development in offsprings.

关 键 词：二硫化碳 性功能 生殖结局 

分 类 号：R135[医药卫生—劳动卫生]