肥胖患者白脂肪组织分泌因子与动脉硬化相关性的研究  

The observation of serum adipocytokines level in obesity atherosclerosis patients

作　　者：王薇[1] 赵广平[1] 李海燕[1] 

机构地区：[1]哈尔滨市第一医院神经内科,黑龙江哈尔滨150010

出　　处：《中国伤残医学》2010年第5期20-22,共3页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:探讨肥胖伴随动脉硬化发生与血清脂肪因子浓度的相关性。方法:收集肥胖伴随动脉硬化患者103例,正常血清55例,以酶联免疫分析法测定血清样本的脂联素、抵抗素、瘦素和内脏脂肪素的浓度,以单链构象多态性多聚酶链反应法检查了2组病人间4种脂肪因子的基因多态性差异。结果:肥胖伞随动脉硬化组血清脂联素、抵抗素和内脏脂肪素浓度较之对照组差异显著(P<0.05),瘦素浓度无差异。同时肥胖伴随动脉硬化组患者的瘦素基因较之对照组有4个碱基的差异。结论:脂肪因子有可能做为肥胖引起的动脉硬化的治疗依据和预测指标。Objective：To investigate the association between serum adipocytokines level and the risk of atherosclerosis.Methods：103 obesity with atherosclerosis and 55 control serum samples were collected.The serum adipocytokines level were measured by ELISA,mutation analysis of 4 adipocytokines genes by PCR-single strand conformation polymorphism （PCR-SSCP） combined with DNA sequencing in two groups of patients.Results：Increase serum concentration of resistin and visfatin were observed in obesity with atherosclerosis group meanwhile serum adiponectin concentration was decrease in same group （ 0.05）,serum concentration of leptin showed no significant difference.By PCR-SSCP,we found 4 base pairs mutation of leptin gene in obesity with atherosclerosis patients.Conclusion：Serum adipocytokines level maybe used as a new diagnosis reference for clinical therapy and predict factor for atherosclerosis emergence.

关 键 词：肥胖 动脉硬化 脂肪因子 

分 类 号：R58[医药卫生—内分泌]