消渴康对DM大鼠早期肾损害及TGF-β_1表达的影响  

Influence Of Xiaoke Kang For DM Rats Renal Damage And TGF-beta 1 Expression

作　　者：李梦[1] 李凤婷[1] 耿建国[1] 

机构地区：[1]首都医科大学中医药学院,北京100069

出　　处：《中医学报》2010年第6期1117-1118,1121,共3页Acta Chinese Medicine

基　　金：北京市教育委员会科技发展计划项目(编号:KM200910025011)

摘　　要：目的:观察消渴康对DM大鼠肾损害及TGF-β1表达的影响。方法:采用单侧肾切除加链脲佐菌素诱导的DM模型,将造模成功后的DM大鼠随机分为模型对照组、氯沙坦对照组和消渴康大、中、小治疗组,观察消渴康对DM大鼠血糖、肾功能、肾脏病理和TGF-β1表达的影响。结果:消渴康对DM大鼠血糖、肾功能和肾脏病理变化均有较好的改善作用,并能明显降低TGF-β1的表达。结论:消渴康对DM大鼠肾脏损害有较好的防治作用。Objective： To observe the influence of xiaoke kang for DM rats renal damage and TGF - beta 1 expression. Methods： using unilateral nephrectomy with urea, assist with chain DM model, DM rats were randomly divided into model control group, losartan quench and large, medium and small group of DM, xiaoke for rats blood sugar, kidney, renal pathology and TGF - beta 1 expression. Results： The thirst of DM rats blood sugar, kidney and kidney function pathological changes has good effect, and can decrease TGF - beta 1 expression. Conclusion： Xiaoke in treating DM rats kidney damage has good control effect.

关 键 词：糖尿病肾病 消渴康 肾损害 大鼠 TGF-Β1 

分 类 号：R285.5[医药卫生—中药学]