乙型肝炎表面抗原携带率与乙型肝炎病毒基因型分布情况调查  

Survey on HBsAg carrier rate and HBV genotypes distribution

作　　者：秦文敬[1] 赵绍林[2] 王娜[1] 傅美丽[1] 王加平[1] 孟晓波[1] 

机构地区：[1]东海县人民医院,江苏东海222300 [2]连云港市第一人民医院,江苏连云港222002

出　　处：《现代生物医学进展》2010年第20期3905-3907,共3页Progress in Modern Biomedicine

摘　　要：目的:了解江苏省东海县高中毕业生乙型肝炎表面抗原(HBsAg)携带率和乙型肝炎病毒(HBV)基因型分布情况。方法:回顾性分析2007年至2009年28512例高中毕业生体检结果,调查乙型肝炎表面抗原阳性率和HBV基因型分布情况。结果:东海县高中毕业生HBsAg携带率为3.81%。男生与女生分别为4.56%与2.94%,有显著差异。2007、2008、2009年毕业的高中生HBsAg阳性率分别为5.37%,4.41%和1.55%,两两比较均有显著差异。HBV基因型B型感染率为32.53%,C型感染率为66.78%,B、C混合型感染率为0.69%。结论:实行乙型肝炎疫苗接种以后,东海县高中毕业生HBsAg携带率低于全国人群平均水平,且呈逐年降低趋势;HBV基因型分布以C型为主,B型次之,B、C混合型很少,未发现B、C型以外的其它基因型。Objective： To know the carrier rate of HBsAg and the distribution of HBV genotypes of high school graduates in Donghai County of Jiangsu Province. Methods： We retrospectively analysed the physical examination of high school graduates from 2007 to 2009, and investigated their HBsAg-positive rate and HBV genotypes distribution. Results： HBsAg carrier rate was 3.81%. Males and females were 4.56% and 2.94% respectively, were significantly different. In 2007, 2008 2009, HBsAg positive rate were 5.37%, 4.41% and 1.55% respectively, were significantly different. HBV genotype B infection rate was 32.53%, genotype C infection rate was 66.78%, genotype B mixed C infection rate was 0.69%. Conclusions： After hepatitis B vaccination, the HBsAg carrier rate of Donghai County high school graduates was below the national average, and was gradually decreasing trend; HBV genotype C was the most, the second was genotype B, genotype B mixed C was the least, not found other genotypes.

关 键 词：乙型肝炎病毒 表面抗原 基因型 

分 类 号：R512.62[医药卫生—内科学]