缺血修饰白蛋白在急性心肌梗死早期诊断中的应用价值  

The Value of Ischemia Modified Albumin in Early Diagnosis of Acute Myocardial Infarction

作　　者：郭长青[1] 蒋维[1] 罗君[1] 沈建江[1] 

机构地区：[1]江苏省中医院检验科,江苏南京210029

出　　处：《航空航天医药》2010年第10期1770-1771,共2页Aerospace Medicine

摘　　要：目的:探讨血清缺血修饰白蛋白在急性心肌梗死早期诊断中的价值。方法:选择76例急性心肌梗死患者,分别于胸痛发作2、4、6、12、24、48 h采静脉血检测其缺血修饰白蛋白、CK、CK-MB及LDH的水平,查体表心电图,并与正常对照组比较,分析缺血修饰白蛋白对急性心肌梗死患者早期诊断的意义。结果:急性心肌梗死患者胸痛2、4、6 h缺血修饰白蛋白水平均明显高于正常对照组,差异有统计学意义(P<0.05),而胸痛12、24、48 h缺血修饰白蛋白水平与正常对照组比较,差异无统计学意义(P>0.05);胸痛2、4、6 h的缺血修饰白蛋白水平明显高于同组胸痛12、24、48 h,差异有统计学意义(P<0.05)。与诊断急性心肌梗死的其他检查比较,缺血修饰白蛋白具有很好的相关性(P<0.01),更好的敏感性。结论:检测缺血修饰白蛋白的水平对于急性心肌梗死早期诊断及治疗有一定临床价值。Objective： To study the value of ischemia modified albumin （IMA） in the early diagnosis of acute myocardial infarction （AMI）. Methods：Seventysix patients with AMI, were selected into the study. Their serum concentration of IMA,CK,CK- MB and LDH were measured respectively at 2, 4, 6, 12, 24 and 48 hours after the onset of chest pain,also, their ECG were test. Results：The serum levels of IMA in those with acute myocardial infarction （AMI） at 2, 4 and 6 hours after the onset were significantly higher than that in normal controls （ P 〈 0. 05 ） in those with acute myocardial infarction （AMI）, the serum levels of IMA were significantly higher at 2, 4 and 6 hours than at 12, 24 and 48 hours after the onset of chest pain （ P 〈 0.05 ）. Compared with test for diagnosis of acute myocardial infarction IMA has a good correlation with them, and has a better sensitivity. Conclusions： The detection of serum levels of IMA is of important value in early diagnosis and treatment of AMI.

关 键 词：急性心肌梗死 缺血修饰白蛋白 心肌缺血 

分 类 号：R541.4[医药卫生—心血管疾病] R446.1[医药卫生—内科学]