甘精胰岛素联合阿卡波糖治疗老年糖尿病的疗效观察  

Acarbose insulin glargine combined on treatment of elderly diabetic

作　　者：王明岗[1] 

机构地区：[1]河南省商丘市第一人民医院内分泌科,467100

出　　处：《中国临床实用医学》2010年第11期1-3,共3页China Clinical Practical Medicine

摘　　要：目的 探讨甘精胰岛素联合阿卡波糖治疗老年糖尿病的临床疗效。方法2008年1月至2010年1月门诊或住院诊治的老年2型糖尿病患者246例，随机分为治疗组126例，对照组120例，治疗组采用甘精胰岛素联合阿卡波糖治疗，对照组采用精蛋白锌重组人胰岛素混合注射液治疗；观察两组临床效果及B细胞功能变化。结果两组血糖达标时间比较，P〈0．05有显著差异性；两组胰岛素日用量、低血糖发生率比较，P〈0．01有显著差异性；治疗前、后C肽＋胰岛素释放试验检测比较P〈0．05有显著差异性。结论甘精胰岛素联合阿卡波糖能达到良好控制血糖，又能减少胰岛素用量，降低低血糖发生率，有效的改善β细胞功能。而且用药依从性良好的治疗老年2型糖尿病方案。Objective To investigate insulin glargine combined acarbose treatment of senile diabetes therapy. Methods 246 cases type 2 diabetes were treated in out - patient or in hospital from January 2008 to January 2010 who were randomly divided into treatment group （126 ） and control group （120）. Treatment group patients treated with insulin glargine combined acarbose treatment, and control group were treated by Protamine zinc mixed recombinant human insulin injection treatment ;To observe clinical effects and β-cell function. Resuits Comparison of two groups of blood glucose time,P 〈 0. 05 ; Two groups of insulin daily dose, the incidence of hypoglycemia,P 〈0. 01 ;Treatment betore and after the C peptide ＋ insulin release test comparison,P 〈 0. 05 ; Conclusion Insulin glargine combined acarbose can achieve good control of blood glucose and reducing insulin dosage, reducing the incidence of low blood sugar, which an improvement of β cell function. It is a good drug compliance and treatment program in elderly type 2 diabetes.

关 键 词：甘精胰岛素 阿卡波糖 老年糖尿病 疗效观察 

分 类 号：R587.1[医药卫生—内分泌]