Ⅰ型干扰素受体在尖锐湿疣皮损及外周血单核细胞中的表达  

The Expression of IFNAR in the Skin Lesion and PBMC of Patients with Condyloma Acuminatum

作　　者：宋军[1] 吉玺[2] 刘雯蓓[3] 马小玲[2] 

机构地区：[1]苏州大学附属第四医院皮肤科,江苏无锡214062 [2]南京医科大学附属南京市妇幼保健院皮肤科,江苏南京210004 [3]皖南医学院附属弋矶山医院皮肤科,安徽芜湖241001

出　　处：《中国皮肤性病学杂志》2010年第10期909-911,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的探讨Ⅰ型干扰素受体(IFNAR)在尖锐湿疣(CA)发病中的可能意义。方法采用逆转录PCR(RT-PCR)法检测CA患者外周血单一核细胞(PBMC)及皮损组织中Ⅰ型干扰素受体两个亚型(IF-NAR1及IFNAR2)的表达,并与正常对照进行对比。结果 CA患者皮损组织中IFNAR1及IFNAR2的表达显著高于正常包皮组织,差异有统计学意义(P<0.001),而PBMC在二者中的表达与对照组比较,差异无统计学意义(P>0.05);IFNAR1及IFNAR2两种亚群在PBMC或CA皮损组织中的表达均呈显著性正相关(r=0.795,0.870,P均<0.001))。结论Ⅰ型干扰素受体在CA皮损组织中代偿性高表达,是参与防卫HPV病毒感染的重要调节因子。Objective To explore the possible role of type Ⅰinterferon receptor （IFNAR） in condyloma acuminatum（CA）.Methods Reverse transcription polymerase chain reaction（RT-PCR） was used to detect the expression of IFNAR1 and IFNAR2 in the skin lesion and PBMC of patients with CA.Results The expression of IFNAR1 and IFNAR2 was significantly up-regulated in the skin lesion of patients with CA（P〈0.001）.The expression of IFNAR1 and IFNAR2 in PBMC showed no significant difference between the patients with CA and the normal controls（P〈0.05）.The expression of IFNAR1 was positively correlated with that of IFNAR2 in both the skin lesion and PBMC of patients with CA.Conclusion The high expression of IFNAR1 the skin lesion may contribute to defending HPV infection.

关 键 词：Ⅰ型干扰素受体 尖锐湿疣 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]