载药聚乳酸羟基乙酸微泡的制备及质量控制研究  

Research on Preparation and Quality Control of Drug-carried Poly lactic-co-glycolic acid Microbubble

作　　者：李奇林[1] 全学模[1] 王佚[1] 

机构地区：[1]重庆医科大学附属儿童医院,重庆400014

出　　处：《生物医学工程学杂志》2010年第5期1051-1055,共5页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(30600579);重庆市教委资助项目(KJ060304)

摘　　要：为探索制备稳定高效的亲水性药物载体微泡的优化处方,采用微泡载药量和体外释放率为检测指标,优选制备工艺。正交试验结果显示在内水相与油相体积比为1∶15,投料比(EB/PLGA)0.04,PVA 5%的条件下所制备的EB-PLGA微泡载药量最为理想。加入附加剂及改变制备方式后,实验组与对照组的体外累积释放率差异具有显著性。由此推论,优化处方能提高亲水性模型药物的载药量,并显著降低突释。This research was aimed to develop the technique and formula for the preparation of stable and effective microbubbles containing hydrophilic drugs.We prepared EB-PLGA microbubbles and evaluated its drug loading and burst release to choose the best technique and formula.The result of optimizing formula was W1/O（1∶15）,EB-PLGA（0.04）,PVA（5%）.The burst release decreased after the addition of supplemental agent and the change of method for preparation.We concluded that the optimizing formula could elevate drug loading and decrease burst release obviously.

关 键 词：声学造影剂 乳酸羟基乙酸共聚物 工艺处方 

分 类 号：R94[医药卫生—药剂学]