PVA水凝胶仿生人工软骨/骨复合植入体的制备与力学性能研究  

On the Preparation and Mechanical Properties of PVA Hydrogel Bionic Cartilage/Bone Composite Artificial Articular Implants

作　　者：孟昊业[1] 郑裕东[1] 黄小山[1] 岳冰清[1] 徐红[2] 王迎军[2] 陈晓峰[2] 

机构地区：[1]北京科技大学材料科学与工程学院,北京100083 [2]华南理工大学材料科学与工程学院,广州510640

出　　处：《生物医学工程学杂志》2010年第5期1056-1061,共6页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(50773004);国家973项目资助(2005CB623902)

摘　　要：针对目前人工软骨假体无生物活性,与软骨下骨结合性能差、易松动等问题,设计和制备一种聚乙烯醇（PVA）-生物活性玻璃（BG）水凝胶人工软骨/骨复合植入体,探讨制备的工艺条件对复合植入体力学性能的影响;研究压缩应变速率、BG含量及PVA水凝胶厚度对复合植入体压缩性能的影响;分析松质骨孔径大小、PVA和BG含量对人工软骨与骨界面剪切强度的影响,并用扫描电镜对界面微观形貌进行了观察。结果表明：随着BG含量、PVA含量以及凝胶厚度的增加,复合植入体的压缩模量也相应增加;松质骨孔径对复合植入体的压缩模量和结合强度均有影响。复合植入体的压缩弹性模量为1.6~2.23 MPa,界面结合处的剪切强度为0.63~1.21 MPa,复合水凝胶与松质骨界面端连接牢固。In view of the problems that conventional artificial cartilages have no bioactivity and are prone to peel off in repeated uses as a result of insufficient strength to bond with subchondral bone,we have designed and prepared a novel kind of PVABG composite hydrogel as bionic artificial articular cartilage/bone composite implants.The effects of processes and conditions of preparation on the mechanical properties of implant were explored.In addition,the relationships between compression strain rate,BG content,PVA hydrogels thickness and compressive tangent modulus were also explicated.We also analyzed the effects of cancellous bone aperture,BG and PVA content on the shear strength of bonding interface of artificial articular cartilage with cancellous bone.Meanwhile,the bonding interface of artificial articular cartilage and cancellous bone was characterized by scanning electron micrascopy.It was revealed that the compressive modulus of composite implants was correspondingly increased with the adding of BG content and the augments of PVA hydrogel thickness.The compressive modulus and bonding interface were both related to the apertures of cancellous bone.The compressive modulus of composite implants was 1.6～2.23 MPa and the shear strength of bonding interface was 0.631.21 MPa.These results demonstrated that the connection between artificial articular cartilage and cancellous bone was adequately firm.

关 键 词：仿生人工软骨 复合植入体 水凝胶 生物活性玻璃 力学性能 

分 类 号：R318.08[医药卫生—生物医学工程]