孤雌胚胎干细胞的组织相容性与印迹状态  

Histocompatibility and Imprinting Status of Parthenogenetic Embryonic Stem Cells

作　　者：薛媛[1] 单智焱[1] 郑重[1] 雷蕾[1] 

机构地区：[1]哈尔滨医科大学组织学与胚胎学教研室,哈尔滨150081

出　　处：《生物医学工程学杂志》2010年第5期1158-1161,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(30671025);黑龙江省教育厅海外学人科研资助项目(1151hz031)

摘　　要：从孤雌胚胎建立的孤雌胚胎干细胞(pESCs)具有与受精的胚胎干细胞(fESCs)相似的全能性和自我更新能力,因免除了胚胎的破坏,所以避免了一些法律和伦理的相关问题。pESCs也具有其特殊的性质,即与卵母细胞供者是组织相容的,因此更适合于细胞与组织的替代治疗。另外,由于pESCs的特殊印迹模式,也为研究基因组印迹的分子机制提供了一个有价值的体外模型系统。The parthenogenetic embryonic stem cells（pESCs） derived from parthenogenetic embryos have the totipotency and proliferation capacity similar to those of the fertilized embryonic stem cells（fESCs）.Therefore,the establishment of pESCs line avoids destroy of embryo and kence may make pESCs less concerns with political and ethical issues.These cells are characterized by their histocompatibility with the oocyte donor and therefore is more suitable for cell and tissue replacement therapy.In addition,because of the typical imprinting status,pESCs also provide a valuable in vitro model system for studying the molecular mechanisms in genomic impringting.

关 键 词：孤雌胚胎干细胞 组织相容性 基因组印迹 

分 类 号：Q813[生物学—生物工程]