脊柱黄韧带骨化的临床影像学研究和meta分析  

Clinical imaging study and meta-analysis of ossification of the ligamentum flavum

作　　者：郭炯炯[1] 杨惠林[1] 唐天驷[1] 张文智[2] 睦瓞骥[1] 

机构地区：[1]苏州大学附属第一医院骨科,215006 [2]香港大学矫形及创伤外科学系

出　　处：《中华骨科杂志》2010年第11期1105-1108,共4页Chinese Journal of Orthopaedics

摘　　要：目的 探讨黄韧带骨化（ossification ofligamentum flavum,OLF）的临床流行病学特征,评估OLF在普通人群中的发病率、形态和分布特点.进行相关OLF流行病学研究的meta分析.方法 对1736名中国南方人进行脊柱的临床影像学研究,分别进行MRI T2加权的矢状位成像,OLF定义为一椎管后方的低信号区,并在CT上证实.根据OLF累及的节段分为单一型、连续型和非连续型;根据矢状位T2加权像上OLF的形态学特征分为三角形、圆形和鸟喙形三种.检索Ovid Medline、PubMed、Embase和中国生物文献数据库（1980年1月至2010年1月）,搜集全部有关OLF的流行病学研究.结果 共有66例志愿者发现有脊柱OLF,其中女52例,男14例.根据该研究新的分型,单一型45例（68.2%）,连续型11例（16.7%）,非连续型10例（15.2%）;形态学上,92个OLF中,17个（18.5%）为三角形,75个（81.5%）为圆形骨化物.纳入研究的OLF流行病学研究共有4篇.结论 OLF在中国南方人群中的患病率约为3.8%（66/1736）,发生率与年龄和性别相关;31.8%的多节段OLF和15.2%的非连续型OLF均提示全脊柱MR检查的必要性.Objective To study the clinical epidemiology of ossification of ligamentum flavum（OLF）and evaluate its characteristics of prevalence,morphology,and distribution in a common population.Some factors associated with its occurrence were analyzed by meta-analysis.Methods A total of 1736 southern Chinese volunteers were recruited by open invitation.T2 weighted MRI sequences of whole spine in all participants were obtained.OLF was identified as an area of low signal intensity located in the posterior part of the spinal canal,and subsequently confirmed by CT scan.The distribution of OLF was classified into three types：isolated type,continuous type and non-continuous type.The morphology of the lesion was classified into triangular,round and beak shapes based on the pattern of ossification on T2 weighted sagittal MRIs.Literatures about OLF were searched in Ovid Medline,PubMed,Embase and Chinese BioMedical Literature Database from January 1980 to January 2010.Results OLF was identified in 66 volunteers including 52 females and 14 males.According to the new classification of the study,there were 45 cases of single type （68.2%）,11 cases of continuous type（16.7%）and 10 cases of non-continuous type（15.2%）.In 92 OLF,there were 17 triangular shape（18.5%）and 75 rounded shape according to morphological classification.A literature review showed that there were only 4 reports related to the prevalence of OLF.Conclusion This study demonstrated that morbidity rate of OLF is about 3.8% in southern Chinese population.The incidence is related to age and gender.It is necessary to perform whole spine MRI examination to detect the multiple level and noncontinous type.

关 键 词：黄韧带 脊柱 META-分析 

分 类 号：R686[医药卫生—骨科学]