吡啶-2,3-二羧酸二乙酯的合成  

The Synthesis of Diethyl Pyridin-2,3-dicarboxylate

作　　者：连伟祥[1] 吴士昊 刘若霖[1] 王嫱[1] 金守征 

机构地区：[1]沈阳化工研究院有限公司新农药创制与开发国家重点实验室,沈阳110021

出　　处：《农药》2010年第11期792-793,821,共3页Agrochemicals

摘　　要：以阳离子交换树脂为催化剂、吡啶-2,3-二羧酸和乙醇为原料,合成吡啶-2,3-二羧酸二乙酯的新方法,收率85.7%,含量93.7%,产品结构经核磁共振氢谱及红外验证,含量由液相色谱分析得到。该合成路线的突出优点为产品收率及含量均较高,合成方法安全环保,几乎可以达到"三废"零排放,符合绿色化工和清洁生产的要求,适合工业化生产。Diethyl pyridin-2,3-dicarboxylate was synthesized according to a new method which used pyridin-2,3-dicarboxylic acid and ethanol as the start materials with cation exchange resin as catalyst,the yield was 85.7% and the content of the product was 93.7%. The structure of the product was confirmed by 1H NMR and IR,and the purity was determined by HPLC. The advantage of this method was the high yield,the good content and almost no ＂three wastes＂ ,which matches the requirements of green chemical industry and clean production,suitable for industrial production.

关 键 词：吡啶-2 3-二羧酸 阳离子交换树脂 吡啶-2 3-二羧酸二乙酯 

分 类 号：TQ225.242[化学工程—有机化工]