神经营养因子对烫伤大鼠不同脑区NO含量的影响  

Effects of NGF and CNTF on NO level in brain of burn rats

作　　者：陈秀青[1] 何成[1] 赵小林[1] 王成海[1] 路长林[1] 

机构地区：[1]上海第二军医大学神经科学研究所,神经生物学教研室,200433

出　　处：《中华整形烧伤外科杂志》1999年第4期292-295,共4页

摘　　要：目的观察烫伤大鼠脑损伤时一氧化氮(NO)含量的变化及神经生长因子(NGF)、睫状神经营养因子(CNTF)分别对其不同脑区 NO 含量的影响,以初步探讨神经营养因子对烫伤大鼠脑组织的保护作用及其可能机制。方法 SD 大鼠侧脑室埋管,麻醉后制成30%TBSAⅢ度烫伤。分成非烫伤组、烫伤组、烫伤+神经生长因子组、烫伤+睫状神经营养因子组。伤后3天,取不同脑区匀浆,测定脑组织中 NO 的含量。结果烫伤后脑组织 NO 含量明显升高,给予 NGF、CNTF 后能明显降低不同脑区 NO 的含量。结论烫伤后脑内 NO 升高可能是造成脑损伤的因素之一,NGF、CNTF 对烫伤后脑组织的保护作用可能与其降低脑组织 NO 含量有关。Objective To investigate the injurious effects of NO to the brain and protective effect of NGF and CNTF following burn injury in rats.Methods Following intubation of the lateral cerebroven- tricle,the rats were divided into four groups:sham burn,burn,burn+NGF,burn+CNTF.The contents of NO in various parts of brain in rats with 30% TBSA third degree scald were measured.Results The con- tents of NO were increased in burned rats.NGF and CNTF could lower the contents of NO.Conclusion The brain injury caused by burns may be associated with increase of NO.The protective effect of NGF and CNTF on the brain of burn rats may be related to lowering of NO.

关 键 词：神经生长因子 CNTF 一氧化氮 烧伤 脑损伤 

分 类 号：R644.02[医药卫生—外科学]