口服二巯基丙磺酸钠对亚急性汞中毒大鼠防治效果的实验研究  

Experimental Study on the Effects of Oral DMPS for Preventing and Treat lug the Subacute Mercury Poisoning in Rats

作　　者：徐兆发[1] 李富君[1] 李革新[1] 刘轩军[1] 

机构地区：[1]中国医科大学公共卫生学院,沈阳110001

出　　处：《工业卫生与职业病》1999年第4期197-200,共4页Industrial Health and Occupational Diseases

基　　金：辽宁省科学技术基金资助项目!962328

摘　　要：给大鼠腹腔注射氯化汞溶液（０．５μｍｏ１Ｈｇ／ｋｇ体重），并同时经口投与０，１ｍｍｏｌ／ｋｇ的ＤＭＰＳ，每天一次，连续５天；或给大鼠腹腔注射氯化汞溶液（２．０μｍｏｌＨｇ／ｋｇ体重），每天一次，连续５天后再经口投与３次０．２ｍｍｏｌ／ｋｇ的ＤＭＰＳ，观察口服ＤＭＰＳ对尿汞和肝肾汞含量以及尿ＡＬＰ和尿ＮＡＧ酶活性的影响。实验结果显示口服ＤＭＰＳ能够促进染汞大鼠的尿汞排泄，降低肝脏、肾皮质的汞含量，减少汞的体负荷。但染汞同时经口投与ＤＭＰＳ，可能会促进汞的肠道再吸收，并引起一过性肝汞含量增高。实验结果未显示ＤＭＰＳ对染汞大鼠的尿酶活性有明显影响，需进一步深入研究。Rats were given an ip injection of 0. 5 (mol Hg/kg body weight as mercuric chlorideand an oral gavage of 0. 1 mmol DMPS/kg per day for five days. After giving an ip injection of 2. 0(mol Hg/kg body weight as mercuric chloride per day for five days, rats received an oral gavage of0.2 mmol DMPS/kg per day for three days. The effects of DMPS administered orally on urinarymercury excretion, mercury concentrations in liver and kidney, and activities of urinary ALP andNAG enzymes were determined. The results showed that oral DMPS could increase the excretion ofurinary mercury, decrease the mercury concentrations in liver and renal cortex, and reduce the bodyload of mercury. However, when mercury and DMPS were administered at the same time, DMPScould promote the re-absorption of mercury via intestinal track and increase the mercury concentrationin liver temporarily. The results showed that DMPS did not result in changes of activities of urinaryenzymes significantly and this may well be worthy of further investigstion.

关 键 词：二巯基丙磺酸钠 尿酶 汞中毒 防治 

分 类 号：R135.13[医药卫生—劳动卫生]