用NM-3K针经纤维支气管镜局部注射治疗耐多药肺结核临床研究  

Local injection therapy by NM-3K needle through fiberoptic bronchoscope on multi-drug resistant pulmonary tuberculosis

作　　者：雷涛 黄春军 程庆山 高卫红 邵伟杰 王光明 

机构地区：[1]宁波市保黎医院,浙江宁波315031

出　　处：《现代实用医学》2010年第9期986-988,共3页Modern Practical Medicine

基　　金：宁波市医学科技项目;编号:200540

摘　　要：目的探讨对耐多药肺结核患者行纤维支气管镜下注药加化疗的临床疗效。方法将纤维支气管镜导至病灶区或相应的段支气管,清除病灶分泌物后,再注入丁胺卡那、左氧氟沙星,配合全身化疗治疗耐多药肺结核50例,与单纯全身化疗50例进行对照研究。结果经纤维支气管镜注药治疗组满21个月时痰菌阴转率88%,病灶有效率92%,均显著高于单纯全身化疗组的52%和74%(均<0.05)。讨论经纤维支气管镜注射药配合全身化疗治疗耐多药肺结核病,疗效显著优于单纯全身化疗,而且未见严重的并发症和毒副反应。Objective To investigate the clinical efficacy of treating multi-drug resistant pulmonary tuberculosis with local injection therapy by NM-3K needle through fiberoptic bronchoscope combined with chemotherapy. Methods The 50 cases of multi-drug resistant pulmonary tuberculosis （MDR-TB） in the experimental group are treated by injecting amikacin（A）, levofioxacin（V） after cleaning up exudation of the focus of infection through fiberoptic bronchoscope combined with chemotherapy while 50 cases in the control group are treated by chemotherapy only. Results By the end of 21-month treatment, the sputum negative conversion rate and focus improvement rate were 88% and 92% respectively in the experimental group, and all these indications were higher than those in the control group with 52% and 74% respectively. No complications and obvious side-effects were observed. Conclusion Local injection therapy by NM-3K needle through fiberoptic bronchoscope combined with chemotherapy is safe and more effective than simple chemotherapy in the treatment of MDR-TB.

关 键 词：结核 肺 微生物敏感性试验 纤维支气管镜 

分 类 号：R521[医药卫生—内科学]