术前口服咪达唑仑用于小儿七氟烷麻醉的临床观察  

Premedication with oral midazolam in children receive sevoflurane general anesthesia

作　　者：姜雪莺[1] 李天佐[1] 李丽[1] 

机构地区：[1]首都医科大学附属北京同仁医院麻醉科,北京100730

出　　处：《中华医学杂志》2010年第37期2633-2635,共3页National Medical Journal of China

基　　金：首都医学发展科研基金（2007-1037）

摘　　要：目的 观察术前口服咪达唑仑对小儿七氟烷麻醉围术期情绪行为的影响.方法 白内障患儿48例,随机数字法分为2组,术前30 min分别口服0.5 mg/kg咪达唑仑（Ⅰ组）和安慰剂（Ⅱ组）.麻醉均采用七氟烷吸入诱导及维持.观察两组患儿术前情绪、术中情况及术后苏醒情况.结果 术前镇静满意率Ⅰ组优于Ⅱ组（P＜0.05）,两组之间术后苏醒时间、恢复室停留时间及苏醒期躁动发生率无明显差异.结论 小儿七氟烷全麻术前口服咪达唑仑0.5 mg/kg是安全的,可以改善入室时患儿的焦虑情绪,但不能降低苏醒期躁动的发生率.Objective To investigate the effect of oral midazolam on sedation, on perioperative emotion and on behavior in children with sevoflurane general anesthesia. Methods 48 children undergoing cataract surgeries were randomly divided into two groups and respectively received 0. 5 mg/kg oral midazolam （Group Ⅰ ）and placebo （Group Ⅱ ） 30 minutes before the operation. Perioperative behavior and emotion status were assessed. Results Satisfactory sedation ratio in group Ⅰ was better than that in group Ⅱ（58. 3% vs 12. 5% , P 〈 0. 05）. There were no differences in emergence time, PACU stay and incidence of emergence agitation between two groups （ P 〉 0. 05 ）. Conclusion 0. 5 mg/kg oral midazolam before sevoflurane general anesthesia in children is safe. It is effective on anxious relief, however it does not decrease the incidence of emergence agitation.

关 键 词：咪达唑仑 术前用药 小儿麻醉 七氟烷 躁动 

分 类 号：R686[医药卫生—骨科学]