SDF-1/CXCR4轴在骨再生修复中的研究进展  

Progress of SDF-1/CXCR4 axis in bone regeneration

作　　者：廖新根[1] 殷明[2] 李士勇[3] 吴梨华[1] 刘哲[1] 付明福[1] 

机构地区：[1]南昌大学研究生院医学部,南昌330006 [2]南昌大学第二附属医院骨科,南昌330006 [3]南昌大学第二附属医院分子医学中心,南昌330006

出　　处：《生命科学》2010年第10期1069-1073,共5页Chinese Bulletin of Life Sciences

摘　　要：基质细胞衍生因子-1(stromal cell-derived factor-1,SDF-1)及其受体CXCR4构成SDF-1/CXCR4轴系统具有许多重要的生物学特性和功能。近年来随着该领域的研究不断深入,越来越多的发现表明,SDF-1/CXCR4轴系统在组织损伤及修复中起着重要作用,其在骨组织再生修复中的作用也日益受到关注。该文主要对SDF-1/CXCR4轴系统的生物学特性及其在骨再生修复中的作用进行综述。The SDF-1/CXCR4 axis system constituted by stromal cell-derived factor -1 （SDF-1） and its receptor CXCR4 has many important biological characteristics and functions. With deepening research in the field in recent years, the growing number of findings suggest that the SDF-1/CXCR4 axis system plays an important role in regeneration and repair of tissue injury , what’s more, the role of SDF-1/CXCR4 axis system in the regeneration of bone tissue are also increasingly concerned. This article reviews the biological characteristics of the SDF-1/CXCR4 axis system and its role in bone regeneration and repair.

关 键 词：基质细胞衍生因子-1 SDF-1/CXCR4轴系统 生物学特性 骨再生修复 

分 类 号：Q813[生物学—生物工程] R683[医药卫生—骨科学]