硫化氢与脓毒症的关系研究进展  

Relationship between hydrogen sulfide and sepsis

作　　者：兰秀彩(综述)[1] 杨光田(审校)[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院急诊科,武汉430030

出　　处：《中国急救医学》2010年第10期944-946,共3页Chinese Journal of Critical Care Medicine

摘　　要：脓毒症是严重创伤、感染及大手术后的常见并发症,其病死率高达25%以上,已成为威胁人类健康的主要疾病之一.硫化氢（H2S）是公认的第三种气体信号分子,目前国内外的研究表明它在脓毒症的病理生理过程中发挥重要的调节作用.因此H2S有关的抗炎药物的研制与应用有重要意义.笔者就目前国内外硫化氢与脓毒症关系的研究现况做一综述.Sepsis is a severe common complication of traunm, infection and major surgery. Its high fatality rate（25% ） has made it one of the major diseases lhreatening mankind. Hydrogen sulfide （H2S） is recognized as the third gaseous signal molecule . In recent years, many researches indicated that H2S exerts important regulatory effects on the pathogenesis of sepsis. So the development of H2S- related anti -inflammatory drug and its clinical implication are quite profoud. This review is focused on the current reserches on the relationship between H2S and sepsis.

关 键 词：硫化氢 脓毒症 黏附分子 信号通路 

分 类 号：R631[医药卫生—外科学]