氨氯地平联合培哚普利对老年高血压患者心率变异性及颈动脉内膜中层厚度的影响  

EFFECTS OF COMBINED TREATMENT BY AMLODIPINE AND PERINDOPRIL ON THE HEART RATE VARIABILITY AND CAROTID ARTERY INTIMA-MEDIA THICKNESS IN ELDERLY HYPERTENSIVE PATIENTS

作　　者：陈群[1,2] 陈莲妹[1,2] 王健康[1,2] 龚俊荣[1,2] 邰晓霞[1,2] 

机构地区：[1]南京医科大学附属苏州医院 [2]苏州市立医院本部心内科,苏州215002

出　　处：《现代预防医学》2010年第22期4358-4360,共3页Modern Preventive Medicine

摘　　要：[目的]研究氨氯地平联合培哚普利对老年高血压患者心率变异性（heart rate variability,HRV）及颈动脉内膜中层厚度（intima-media thickness IMT）的影响。[方法]收集2008年1月～2009年12月在我科住院的老年高血压患者90例,随机分为氨氯地平组、培哚普利组和氨氯地平联合培哚普利组。各组治疗前及治疗24周后行24 h动态血压检测（24-hour ambulatory blood pressure ABP）、HRV分析及颈动脉IMT测定,结果进行统计学分析。[结果]各组治疗后血压均明显下降（P﹤0.05）。氨氯地平组治疗后颈动脉IMT减少（P﹤0.05）,但HRV无明显差异（P﹥0.05）。培哚普利组治疗后颈动脉IMT无明显变化（P﹥0.05）,但HRV显著升高（P﹤0.01）。氨氯地平联合培哚普利组治疗后颈动脉IMT减少（P﹤0.05）,同时HRV显著升高（P﹤0.01）。[结论]氨氯地平及培哚普利对老年高血压患者降压疗效相似。氨氯地平能减少颈动脉IMT,培哚普利能提高HRV,两药联合应用能使老年高血压患者在降压同时获益更多。[Objective] To evaluate the effects of combined treatment by amlodipine and perindopril on heart rate vari-ability（HRV） and carotid artery intima-media thickness（IMT） in elderly hypertensive patients.[Methods] A total of 90 el-derly patients with hypertension from January 2008 to December 2009 were randomly divided into amlodipine group,perindopril group and amlodipine plus prindopril group.24-hour ABP,HRV and carotid artery IMT were measured before and after taking drugs for 24 weeks.[Results] Blood pressure of patients in three groups were significantly lower than pre-treatment（P ﹤ 0.05）.In the amlodipine group,the carotid artery IMT decreased significantly after treatment（P﹤0.05）,whereas HRV had no apparent change（P﹥0.05）.In the perindopril group,the carotid artery IMT were not changed obviously（P﹥0.05）,whereas HRV increased significantly after treatment（P﹤0.01）.In the amlodipine plus prindopril group,carotid artery IMT decreased significantly（P﹤0.05） and HRV increased significantly after treatment（P﹤0.01）.[Conclusion] Amlodipine has the same effect of decreasing blood pressure with prindopril in elderly hypertensive patients.Amlodipine combined with prindopril treatment has additional effect on the decreasing of carotid artery IMT and increasing of HRV.

关 键 词：高血压 心率变异性 颈动脉内膜中层厚度 氨氯地平 培哚普利 

分 类 号：R972.4[医药卫生—药品]